Article
Circulating Melanoma Cells: An evolving instrument in the diagnostic of uveal melanoma
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Published: | August 20, 2013 |
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We previously determined the presence of circulating melanoma cells (CMCs) in uveal melanoma patients without metastatic disease and correlated the presence with other prognostic risk factors. The aim of this study was to further evaluate CMCs in uveal melanoma patients as diagnostic and prognostic tool. Successful identification of circulating tumor cells was correlated with characteristics of the primary tumor and cultured cells. Different markers were evaluated both in the primary tissues as well as in the propagated cultured cells. A good correlation between the examined tissue and cell samples was shown. The detection of CMCs is a useful tool for prognostic evaluation and determination of therapeutic strategies.