gms | German Medical Science

12th Malaria Meeting

Malaria Group / Section Antiparasitic Chemotherapy of the Paul-Ehrlich-Society (PEG e. V.) in cooperation with the German Society for Tropical Medicine and International Health (DTG e. V.) and the German Society for Parasitology (DGP e. V.)

14.11. - 15.11.2014, Bonn

The infection-treatment approach to immunization against Plasmodium falciparum malaria

Meeting Abstract

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  • Benjamin Mordmüller - Institute of Tropical Medicine, University of Tuebingen, Tuebingen, Germany

12th Malaria Meeting. Bonn, 14.-15.11.2014. Düsseldorf: German Medical Science GMS Publishing House; 2014. Doc14mal12

doi: 10.3205/14mal12, urn:nbn:de:0183-14mal125

Published: December 17, 2014

© 2014 Mordmüller.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



The concept of infection-treatment immunization approach to immunization against malaria will be introduced and an overview of past, ongoing and planned clinical trials is given. The ongoing TÜCHMI-002 trial ( Identifier NCT02115516) is presented in detail. TÜCHMI-002 is a phase 1 clinical trial to assess safety, tolerability and protective efficacy of intravenous immunization with cryopreserved Plasmodium falciparum sporozoites under chemoprophylaxis. Sporozoites are inoculated three times in 4-week intervals in doses of up to 51200 parasites under chemoprophylaxis with chloroquine or azithromycin and chloroquine. Following immunization, protective efficacy is tested using controlled human malaria infection (CHMI) with a homologous parasite strain. Results of the safety analysis of all groups and preliminary CHMI outcomes for the low and middle dose group (12800 sporozoites) will be presented.