Artikel
The infection-treatment approach to immunization against Plasmodium falciparum malaria
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Veröffentlicht: | 17. Dezember 2014 |
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Gliederung
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The concept of infection-treatment immunization approach to immunization against malaria will be introduced and an overview of past, ongoing and planned clinical trials is given. The ongoing TÜCHMI-002 trial (ClinicalTrials.gov Identifier NCT02115516) is presented in detail. TÜCHMI-002 is a phase 1 clinical trial to assess safety, tolerability and protective efficacy of intravenous immunization with cryopreserved Plasmodium falciparum sporozoites under chemoprophylaxis. Sporozoites are inoculated three times in 4-week intervals in doses of up to 51200 parasites under chemoprophylaxis with chloroquine or azithromycin and chloroquine. Following immunization, protective efficacy is tested using controlled human malaria infection (CHMI) with a homologous parasite strain. Results of the safety analysis of all groups and preliminary CHMI outcomes for the low and middle dose group (12800 sporozoites) will be presented.