gms | German Medical Science

GMS Journal for Medical Education

Gesellschaft für Medizinische Ausbildung (GMA)

ISSN 2366-5017

Molecular diagnostics of short- and long-term outcomes in perinatal asphyxia

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GMS Z Med Ausbild 2007;24(4):Doc172

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/journals/zma/2007-24/zma000466.shtml

Eingereicht: 25. September 2007
Überarbeitet: 25. September 2007
Angenommen: 1. Oktober 2007
Veröffentlicht: 14. November 2007

© 2007 Golubnitschaja.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Abstract

Perinatal asphyxia is the leading cause of infant mortality and morbidity. The incidence rate is 3-4 in 1.000 newborns. Low oxygen supply at a birth may cause kidney insufficiency, damage of CNS and cardiomyopathy, and may predispose to neurodegenerative, cardiovascular and cancer diseases as well as to senescence in adulthood. Extent of organ damage depends on asphyxia severity and individual stress reactions. Currently no precise diagnostic system is developed, in order to estimate individual short- and long-term outcomes in perinatal asphyxia. There is an obvious need in a development of a precise early and even prevent diagnostic approaches which might predict individual stress reaction as well as outcomes. Attractive approaches may be non-invasive blood transcriptome and proteome based methodology. Proteins such as S100 and COX2 have been shown to be stably highly expressed to blood and even urine of asphyxiated newborns. The same molecular markers have been demonstrated to be highly increased in blood proteome of Alzheimer’s and Parkinson’s patients, patients with glaucoma, breast and prostate cancer. In order to differentiate among distinct pathologies asphyxiated newborns are predisposed for, individual blood proteome/transcriptome patterns should be investigated in correlation with corresponding pathologies. Molecular imaging methodology, which includes disease genomics, transcriptomics and proteomics should be apply. A combination of multidisciplinary expertise for those research projects is highly desirable, which includes neonatology, paediatrics, ophthalmology, neurology, radiology, biotechnology, etc. Projects applying for financial EU-contribution should consider the issue. EUROPET should support this kind of activities.