Artikel
Chromosome 7p11.2(EFFR) and 7q36.1(XRCC2) variants influence glioma risk
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Veröffentlicht: | 28. April 2011 |
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Gliederung
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Objective: Gliomas are the commonest primary brain tumors and for many patients the disease is eventually lethal. Its cause is largely unknown. To identify genetic risk variants for glioma, we have analysed genome-wide association (GWA) study data on 4,147 glioma cases and 7,435 controls.
Methods: Patients and controls were genotyped for 424,460 common tagging single nucleotide polymorphisms (SNPs). We also correlated SNPs to tumor histology and prognosis.
Results: We observed a significant association between glioma and two SNPs, rs11979158 and rs2252586, at chromosome band 7p11.2 which encompasses the EGFR gene (P = 7.03x10-8 and 7.89x10-8; per allele odds ratio, 1.23 and 0.85 respectively) and rs2040639 at 7q36.1 (P=2.81x10-7; per allele odds ratio, 0.86) annotating the XRCC2 gene. The 7p11.2 and 7q36.1 associations were independent of tumor subtype, compatible with driver effects on tumorigenesis. There was no association between either SNP and prognosis.
Conclusions: Common genetic variation at chromosome band 7p11.2 and 7q36.1 are associated with susceptibility to glioma and implicate variation in EGFR and XRCC2 in disease etiology.