gms | German Medical Science

62nd Annual Meeting of the German Society of Neurosurgery (DGNC)
Joint Meeting with the Polish Society of Neurosurgeons (PNCH)

German Society of Neurosurgery (DGNC)

7 - 11 May 2011, Hamburg

Chromosome 7p11.2(EFFR) and 7q36.1(XRCC2) variants influence glioma risk

Meeting Abstract

  • M. Simon - Neurochirurgische Universitätsklinik, Bonn, Germany
  • F.J. Hosking - Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK
  • S. Shete - Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
  • D. Zelenika - Centre National de Génotypage, Evry Cedex, France
  • Y. Marie - Université Pierre et Marie Curie-Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moëlle épinière (CRICM) UMR-S975, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service de Neurologie Mazarin, Paris, France
  • K. Gousias - Neurochirurgische Universitätsklinik, Bonn, Germany
  • H.E. Wichmann - Institut für Epidemiologie, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; Institut für Medizinische Informatik, Biometrie and Epidemiologie, Lehrstuhl für Epidemiologie, Ludwig-Maximilians-Universität, Munich, Germany
  • K. Hemminki - Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany
  • M. Lathrop - Centre National de Génotypage, Evry Cedex, France; Foundation Jean Dausett-CEPH, Paris, France
  • M. Bondy - Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
  • R.S. Houlston - Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK
  • M. Sanson - Université Pierre et Marie Curie-Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moëlle épinière (CRICM) UMR-S975, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service de Neurologie Mazarin, Paris, France

Deutsche Gesellschaft für Neurochirurgie. Polnische Gesellschaft für Neurochirurgen. 62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH). Hamburg, 07.-11.05.2011. Düsseldorf: German Medical Science GMS Publishing House; 2011. DocMI.05.06

DOI: 10.3205/11dgnc215, URN: urn:nbn:de:0183-11dgnc2150

Published: April 28, 2011

© 2011 Simon et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.


Outline

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Objective: Gliomas are the commonest primary brain tumors and for many patients the disease is eventually lethal. Its cause is largely unknown. To identify genetic risk variants for glioma, we have analysed genome-wide association (GWA) study data on 4,147 glioma cases and 7,435 controls.

Methods: Patients and controls were genotyped for 424,460 common tagging single nucleotide polymorphisms (SNPs). We also correlated SNPs to tumor histology and prognosis.

Results: We observed a significant association between glioma and two SNPs, rs11979158 and rs2252586, at chromosome band 7p11.2 which encompasses the EGFR gene (P = 7.03x10-8 and 7.89x10-8; per allele odds ratio, 1.23 and 0.85 respectively) and rs2040639 at 7q36.1 (P=2.81x10-7; per allele odds ratio, 0.86) annotating the XRCC2 gene. The 7p11.2 and 7q36.1 associations were independent of tumor subtype, compatible with driver effects on tumorigenesis. There was no association between either SNP and prognosis.

Conclusions: Common genetic variation at chromosome band 7p11.2 and 7q36.1 are associated with susceptibility to glioma and implicate variation in EGFR and XRCC2 in disease etiology.