Artikel
Nasal complications involving the use of a calcitonin nasal spray for osteoporosis
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Veröffentlicht: | 8. August 2007 |
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Gliederung
Text
Calcitonin in the form of nasal spray is widely used for the treatment of postmenopausal osteoporosis as well as for other skeletal diseases. Generally it has low percentage of side-effects that are usually mild and of local character. We present two cases of postmenopausal women with osteoporosis being treated with intranasal calcitonin in which a septum perforation and a septum-concha synechiae led the patients to our ENT department. These lesions after clinical and laboratory examination were attributed to the use of intranasal calcitonin. A questionnaire submitted to a greater number (n=238) of women undergoing treatment with calcitonin, as well as nasal cytology showed inflammatory changes of nasal mucosa in those patients who gave a positive answer for intranasal side-effects. We review the literature on nasal calcitonin use and discuss the possible mechanisms causing local side-effects.
(Literature from the corresponding author)