Article
Influence of the stretching properties of pigmentepithelial detachment (PED) in regard to a rupture in the pigmentepithelium (RIP) during intravitreal anti-VEGF-therapy
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Published: | June 15, 2011 |
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Background: Observations showed that some patients with AMD and PED developed a RIP during an intravitreal anti-VEGF-therapy. Purpose of the study was to make out a criterion for the predictability of the rupture development.
Methods: Two lengths were measured by spectral domain OCT: the basis and the arch of the PED within 11 eyes (6 ♀; 5 ♂; mean age 73.8 years) that showed no RIP before and after anti-VEGF therapy. The pictures have been exported in proportion 1:1 micrometers into the Inskape programme to designate the relative proportion between the length of the PED-basis and the PED-arch through vector analysis. These results have been compared to 12 eyes (7 ♀; 5 ♂; mean age 71.8 years) who developed a RIP while 12 weeks after injection.
Results: Prior to therapy the average of the arc length was 2.74 and of the basislenght 2.57 with a stretchingratio (arc length/basislength) of 1.97. The stretchingratio after 12 weeks averaged 1.04 (p=0.15). In the group of RIP-patients the stretchingratio before and after therapy was marginal significant (0.06).
Conclusions: During the formation of a PED accrues a quantitatively stretching of the RPE, that can also form back. The dimension of the stretching seems to be an issue within the development of a RIP.