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83rd Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

16.05. - 20.05.2012, Mainz

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Expression of matrix metalloproteinases (MMP-2 and MMP-9) in recurrent respiratory papillomas and laryngeal carcinoma: clinical and morphological parallels

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  • corresponding author Vykintas Liutkevicius - Departmen of Otorhinolaryngology, Lithuanian University of Helth Sciences, Kaunas, Lithuania
  • Virgilijus Uloza - Department of Otorhinolaryngology, Lithuanian University of Helth Sciences, Kaunas, Lithuania
  • Dalia Pangonyte - Department of Cardiac Pathology, Institute of Cardiology, Lithuanian University, Kaunas, Lithuania
  • Vaiva Lesauskaite - Department of Cardiac Pathology, Institute of Cardiology, Lithuanian University, Kaunas, Lithuania

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. 83. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. Mainz, 16.-20.05.2012. Düsseldorf: German Medical Science GMS Publishing House; 2012. Doc12hnod266

doi: 10.3205/12hnod266, urn:nbn:de:0183-12hnod2663

Published: April 4, 2012

© 2012 Liutkevicius et al.
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Introduction: The matrix metalloproteinases (MMP) consist a family of proteolytic zinc-containing enzymes, which are responsible to degrade extracellular matrix components and play an important role in the physiological and pathological remodelling of tissues. They role in the development of malignant neoplasia is under investigation. The task of the present study was to investigate the expression of MMP-2 and MMP-9 in recurrent respiratory papillomas (RRP) and accomplish a comparative analysis with those in laryngeal squamous cell carcinoma (LSCC).

Methods: The immunohistochemical expression of MMP-2 and MMP-9 was investigated in specimens taken from RRP (n = 38) and LSCC (n = 39) patient groups, and the normal tissue of vocal fold (n = 12, control group). The expression of MMP-2 and MMP-9, both in epithelium and stroma cells, was graded on a semiquantitative scale, ranging from 0 (no expression) to 18 points (high expression).

Results: Significant differences in the expression of MMP-2 and MMP-9, both in epithelium and stroma among the RRP, LSCC patients and control group (epithelium) with the LSCC group having the highest MMPs expression scores were revealed. However, no significant correlations among expression of MMPs and clinical and/or morphological features were found in the group of RRP patients. The MMP-2 stroma value of 10.4 points was determined as the optimum point (limiting value) for separating RRP and LSCC patient groups.

Conclusions: Results of the present study indicate that the expression of both MMP-2 and MMP-9 are up-regulated early in development of RRP. These results seem promising, as they may improve our understanding of the molecular events leading to the papilloma formation and development, however, further research is needed.