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81st Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

12.05. - 16.05.2010, Wiesbaden

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AQP5 -1364A>C Promotor-polymorphsim in squamous cell carcinoma of the oro- and hypopharynx

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  • author presenting/speaker Sebastian Zander - Klinik für Hals-Nasen-Ohrenheilkunde, Essen, Germany
  • Hagen Bachmann - Klinik für Pharmakogenetik, Essen, Germany
  • Michael Adamzik - Institut für Klinik für Anästhesiologie und Intensivtherapie, Essen, Germany
  • Winfried Siffert - Institut für Pathologie und Neuropathologie, Essen, Germany
  • Agnes Bankfalvi - Institut für Pathologie und Neuropathologie, Essen, Germany
  • Alexander Kerem - Klinik für Hals-Nasen-Ohrenheilkunde, Essen, Germany
  • Stephan Lang - Klinik für Hals-Nasen-Ohrenheilkunde, Essen, Germany
  • corresponding author Götz Lehnerdt - Klinik für Hals-Nasen-Ohrenheilkunde, Essen, Germany

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery. 81st Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery. Wiesbaden, 12.-16.05.2010. Düsseldorf: German Medical Science GMS Publishing House; 2010. Doc10hno038

doi: 10.3205/10hno038, urn:nbn:de:0183-10hno0382

Published: July 6, 2010

© 2010 Zander et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Aquaporins are small proteins of the cell membrane which allow a selective transport of water through the cell membrane. Some AQP isoforms showed a high level of expression in tumour cells, particularly in very aggressive tumours. New results concerning the part of AQPs in terms of cell migration processes suggest that the expression of AQP in tumours and tumour vessel has an adverse effect on tumour expansion and metastasis. Repression of AQP could be an interesting new approach to design a target tumour therapy in future.

The C-allele of the promoter polymorphism AQP5 -1364A>C is associated with reduced expression of AQP5. It has to be analysed if there is genotype-related association between the functional AQP5 -1364A>C polymorphism and the clinical outcome.

We analysed the genotypes of 182 patients with squamous cell carcinoma of the oro- and hypopharynx. The distribution of the genotypes was 115 AA, 59 AC and 8 CC. The Kaplan-Meier-analysis and the log-rank-test did not show a significant genotype-related difference with regard to the overall survival (log rank p=0.65), the tumour-related survival (log rank p=0.502) and the relapse-free survival (log rank p=0.649).

However, in our patients the -1364A>C (AQP5) genotype did not show a prognostic significance in squamous cell carcinoma of the pharynx.

Outline

References

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Chae YK, et al. Expression of AQP5 Promotes Tumor Invasion in Human Non Small Cell Lung Cancer. PLoS ONE. 2008;3:e2162.
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Yang JH, et al. Expression and localization of aquaporin-5 in the epithelial ovarian tumors. Gynecol Oncol. 2006;100:294-9.
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Woo J, et al. The effect of aquaporin 5 overexpression on the Ras signaling pathway. Biochemical and Biophysical Research Communications. 2008;367:291–8.