gms | German Medical Science

German Congress of Orthopaedics and Traumatology (DKOU 2016)

25.10. - 28.10.2016, Berlin

Epidemiology of Osteoporosis and fragility fractures according to regional data

Meeting Abstract

  • presenting/speaker Giuseppe Maccagnano - Universitary Hospital - Orthopedic and Traumatology Unit, Bari, Italy
  • Angela Notarnicola - Universitary Hospital - Orthopedic and Traumatology Unit, bari, Italy
  • Simona Mudoni - Regional Epidemiological Observatory, Bari, Italy
  • Silvio Tafuri - Department of Biomedical Science and Human Oncology;, Bari, Italy
  • Biagio Moretti - University of Bari, Orthopedic Surgery, Bari, Italy

Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2016). Berlin, 25.-28.10.2016. Düsseldorf: German Medical Science GMS Publishing House; 2016. DocWI44-1540

doi: 10.3205/16dkou302, urn:nbn:de:0183-16dkou3021

Published: October 10, 2016

© 2016 Maccagnano et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at



Objectives: Osteoporosis is a metabolic disease of the skeleton most frequently in the world, with a prevalence estimated at 200 million people. Although in recent years there is an increase in the prevalence of osteoporosis in male patients, the disease is generally more common in females; also there are many diseases that potentially increase the risk of osteoporosis (diabetes, chronic inflammatory gastrointestinal, kidney disease).

The aim of our study was to evaluate the incidence of osteoporosis in people suffering from certain chronic conditions, such as asthma, diabetes mellitus, heart disease, colitis and Crohn's disease, kidney disease and thyroid disease, through the analysis of epidemiological data related currents to the years 2008-2013.

Methods: The sources of data considered were: hospital discharge records, stock of pharmaceutical prescriptions drug-end A and archive serviceable NHS.

We created an algorithm for extracting select cohorts of subjects suffering from different diseases prevalent for 2008, considering each person who, in 2008, had a hospitalization for the disease itself or a prescription charge exemption for the disease or at least one prescription a drug tracer (eg. insulin for diabetes, levothyroxine for thyroid disease, etc.). Using these extraction algorithms, have been selected cohorts of subjects prevalent asthma, diabetes mellitus, heart disease, colitis and Crohn's disease, kidney disease and thyroid disease in the year 2008.

These cohorts were linked with sources of health data for the years 2008-2013, to search for events tracers of osteoporosis (hospitalization for pathological fractures, prescription anti-osteoporotic). In this manner it was calculated the prevalence of osteoporosis in cohorts of subjects with chronic diseases.

Data processing was made with STATA software MP11.

Results: The data analysis shows an average prevalence of osteoporosis 14.6% in patients treated by chronic diseases; in particular, the highest prevalence of osteoporosis is known in subjects with nephropathy (38.5%), followed by the subjects with thyroid diseases (16.2%), heart disease (16%), diabetes (14.7%), chronic inflammatory bowel disease (12.7%). The prevalence appears to be less elevated in patients with asthma (8.8%).

As for the M / F ratio, this appears to be consistently low, resulting in minimum osteoporotic subjects with thyroid diseases (5/95) and greatest in patients with asthma (2/8).

Conclusions: The analysis of current data shows that osteoporosis is a frequent occurrence in patients with chronic disease; therefore, it is desirable strengthening multidimensional intervention on these patients, by taking charge, the correction of modifiable risk factors and the inclusion of screening for osteoporosis in the clinical diagnostic pathways.