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Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)

09.09. - 12.09.2020, virtuell

Extra-articular and non-axial manifestations in patients with early axial spondyloarthritis from the CORSAR cohort during 3 years of follow-up, managed according to the T2T strategy

Meeting Abstract

  • Daria Rumiantceva - V.A. Nasonova Research Institute of Rheumatology, Laboratory of spondyloarthritis and psoriatic arthritis, Moscow
  • Shandor Erdes - V.A. Nasonova Research Institute of Rheumatology, Laboratory of spondyloarthritis and psoriatic arthritis, Moscow
  • Tatiana Dubinina - V.A. Nasonova Research Institute of Rheumatology, Medical social research laboratory, Moscow
  • Olga Krichevskaya - V.A. Nasonova Research Institute of Rheumatology, Medical social research laboratory, Moscow
  • Anastacia Demina - V.A. Nasonova Research Institute of Rheumatology, Medical social research laboratory, Moscow

Deutsche Gesellschaft für Rheumatologie. Deutsche Gesellschaft für Orthopädische Rheumatologie. Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh). sine loco [digital], 09.-12.09.2020. Düsseldorf: German Medical Science GMS Publishing House; 2020. DocSpA.42

doi: 10.3205/20dgrh159, urn:nbn:de:0183-20dgrh1595

Published: September 9, 2020

© 2020 Rumiantceva et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.


Outline

Text

Introduction: According to ASAS, extra-articular (uveitis, psoriasis, inflammatory bowel diseases) and non-axial (arthritis, dactylitis, enthesitis) manifestations refer to the classification criteria for axial spondyloarthritis (axSpA). However, currently there are few studies evaluating the dynamics of extra-articular and non-axial manifestations in patients with early axSpA.

Objective: to evaluate the dynamics of extra-articular and non-axial manifestations in patients with early axSpA managed according to the T2T strategy during 3 years of active monitoring.

Methods: Currently the CORSAR cohort includes 175 patients with early axSpA (ASAS criteria, 2009) with inflammatory back pain duration < 5 years. The analysis included 56 patients who were followed for at least 3 years. Patients were examined in accordance with ASAS recommendations at inclusion and after 3 years, of whom there were 30 (53.5%) men and 26 (46.5%) women, p>0.05. Patients’ mean age was 27.8 (5.8) years, and mean disease duration was 21.2 (16.2) months. At baseline there were 31 (55.3%) AS patients (according to the modified New York criteria 1984), and 25 (44.7%) patients with nonradiographic axSpA (nr-axSpA). 53 (94.6%) patients were positive for HLA B27. All patients were followed and managed according to treat-to-target (T2T) strategy.

Results: At baseline patients with early axSpA had significantly higher counts for such non-axial manifestations as arthritis, dactylitis, and enteritis, than after 3 years of follow-up (Table 1 [Tab. 1]). As for the extra-articular manifestations, the number of patients with a history of uveitis did not change during the follow-up period, psoriasis was documented at baseline and in 3 years in one patient only, and no patients had inflammatory bowel disease (Table 1 [Tab. 1]).

Conclusion: Enthesitis and arthritis were the most common non-axial manifestations of the early axSpA, which significantly decreased after 3 years of active monitoring being managed according to the T2T strategy. No new cases of extra-articular axSpA manifestations were registered during 3 years of FUP.

Disclosures: None declared