gms | German Medical Science

70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

12.05. - 15.05.2019, Würzburg

Metacognitive therapy in OCD – modulation of local field potentials

Metakognitive Therapie bei OCD – Modulation von lokalen Feldpotentialen

Meeting Abstract

  • presenting/speaker Assel Saryyeva - Medizinische Hochschule Hannover, Neurochirurgie, Hannover, Deutschland
  • Lotta Winter - Medizinische Hochschule Hannover, Neurochirurgie, Hannover, Deutschland
  • Kai Kahl - Medizinische Hochschule Hannover, Neurochirurgie, Hannover, Deutschland
  • Mesbah Alam - Medizinische Hochschule Hannover, Neurochirurgie, Hannover, Deutschland
  • Kerstin Schwabe - Medizinische Hochschule Hannover, Neurochirurgie, Hannover, Deutschland
  • Hans E. Heissler - Medizinische Hochschule Hannover, Neurochirurgie, Hannover, Deutschland
  • Joachim K. Krauss - Medizinische Hochschule Hannover, Neurochirurgie, Hannover, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie. Würzburg, 12.-15.05.2019. Düsseldorf: German Medical Science GMS Publishing House; 2019. DocV300

doi: 10.3205/19dgnc319, urn:nbn:de:0183-19dgnc3197

Published: May 8, 2019

© 2019 Saryyeva et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.


Outline

Text

Objective: We here present data of an innovative experimental paradigm along the example of one patient with treatment resistant obsessive-compulsive disorder (trOCD) who underwent implantation of bilateral electrodes for deep brain stimulation (DBS). The patient had not received metacognitive therapy (MCT) before.

Methods: DBS electrodes were implanted bilaterally with stereotactic guidance in the bed nucleus of the stria terminalis/internal capsule (BNST/IC). Electrodes were externalized via extension cables, yielding the opportunity to measure local field potentials (LFPs) directly from the BNST/IC via microelectrode recordings. The experimental procedure was designed as follows: a) baseline recording of LFPsfrom the BNST/IC; b) LFP recording during presentation of specific, individualized OCD pictures selected from the Maudsley Obsessive-Compulsive Stimuli Set mixed with neutral pictures taken from the international affective pictures system (IAPS); c) Application of 4 units with elements of MCT during 3 consecutive days; d) post-MCT microelectrode recordings from the BNST/IC.

Results: We found increased frontal activity during OCD related visual stimulus condition compared to neutral visual stimulus, which was condensed in an increased anteriorisation of the brain electrical field. After application of MCT, the frequency and amplitude of LFPs from the BNST/IC was reduced.

Conclusion: Implantation of electrodes for treating pathologic neuronal circuits associated with psychiatric disorders offer the opportunity to gather data from neuronal structures, and to compare pre-post effects of treatment. We here demonstrate for the first time effects of reaction to visual OCD stimuli on the electrical activity of neuronal structures that are presumably involved in the etiology of OCD. Further, we demonstrate that applying only 4 sessions with elements of MCT alter LFPs in frequency and amplitude, thereby suggesting that MCT may alter neuronal activity associated with OCD. These results may give important cues for the neurobiological underpinnings of psychotherapy.