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70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

12.05. - 15.05.2019, Würzburg

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Quantification of spinal cord compression using T1 mapping in patients with cervical spinal canal stenosis

Quantifizierung der Myelonkompression in degenerativen Spinalkanalstenosen mittels T1-mapping – Perspektiven für die klinische Anwendung

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  • presenting/speaker Ilko Maier - Universitätsmedizin Göttingen, Neurologie, Göttingen, Deutschland
  • Sabine Hofer - Max-Planck-Institut für biophysikalische Chemie, Göttingen, Deutschland
  • Arun A. Joseph - Max-Planck-Institut für biophysikalische Chemie, Göttingen, Deutschland
  • Dietmar Merboldt - Max-Planck-Institut für biophysikalische Chemie, Göttingen, Deutschland
  • Eva Eggert - Universitätsmedizin Göttingen, Neurologie, Göttingen, Deutschland
  • Daniel Behme - Universitätsmedizin Göttingen, Neuroradiologie, Göttingen, Deutschland
  • Katharina Schregel - Universitätsmedizin Göttingen, Neuroradiologie, Göttingen, Deutschland
  • Christian von der Brelie - Universitätsmedizin Göttingen, Neurochirurgie, Göttingen, Deutschland
  • Veit Rohde - Universitätsmedizin Göttingen, Neurochirurgie, Göttingen, Deutschland
  • Jan Koch - Universitätsmedizin Göttingen, Neurologie, Göttingen, Deutschland
  • Marios Nikos Psychogios - Universitätsmedizin Göttingen, Neuroradiologie, Göttingen, Deutschland
  • Jens Frahm - Max-Planck-Institut für biophysikalische Chemie, Göttingen, Deutschland
  • Jan Liman - Universitätsmedizin Göttingen, Neurologie, Göttingen, Deutschland
  • Mathias Bähr - Universitätsmedizin Göttingen, Neurologie, Göttingen, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie. Würzburg, 12.-15.05.2019. Düsseldorf: German Medical Science GMS Publishing House; 2019. DocV157

doi: 10.3205/19dgnc184, urn:nbn:de:0183-19dgnc1844

Published: May 8, 2019

© 2019 Maier et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

Text

Objective: Degenerative changes of the cervical spinal column are the most common cause of spinal cord lesions in the elderly. Conventional clinical, electrophysiological and radiological diagnostics of spinal cord compression are often inconsistent.

Methods: The feasibility and diagnostic potential of a novel T1 mapping method at 0.5 mm resolution and 4 s acquisition time was evaluated in 14 patients with degenerative cervical spinal canal stenosis (SCS) and 6 healthy controls. T1 mapping was performed in axial sections of the stenosis as well as above and below. All subjects received standard T2-weighted MRI of the cervical spine (including SCS-grading 0-III), electrophysiological and clinical examinations.

Results: Patients revealed significantly decreased T1 relaxation times of the compressed spinal cord within the SCS (912±53 ms, mean ± standard deviation) in comparison to unaffected segments above (1027±39 ms, p<0.001) and below (1056±93 ms, p<0.001) (see Figure 1 [Fig. 1]). There was no difference in mean T1 in unaffected segments in patients (p=0.712) or between segments in controls (p=0.443). Moreover, T1 values were significantly lower in grade II (881±46 ms, p=0.005) than in grade I SCS (954±29 ms) (see Figure 2 [Fig. 2]). Patients with central conduction deficit tended to have lower T1 values within the SCS than patients without (909±50 ms vs 968±7 ms, p=0.069).

Conclusion: Rapid high-resolution T1 mapping is a robust MRI method for quantifying spinal cord compression in patients with cervical SCS. It promises additional diagnostic insights and warrants more extended patient studies.