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70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

12.05. - 15.05.2019, Würzburg

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ABO blood type is an inherited risk factor for pulmonary embolism in neurocritical care patients

Blutgruppe als Risikofaktor für eine Lungenemboliebei Patienten auf der Neurochirurgisch-Neurologischen Intensivstation

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  • presenting/speaker Daniel Dubinski - Universitätsklinikum Frankfurt, Klinik für Neurologie, Frankfurt am Main, Deutschland
  • Fee Keil - Goethe Universität Frankfurt, Klinik für Neuroradiologe, Frankfurt am Main, Deutschland
  • Sae-Yeon Won - Universitätsklinikum Frankfurt, Klinik für Neurologie, Frankfurt am Main, Deutschland
  • Bedjan Behmanesh - Universitätsklinikum Frankfurt, Klinik für Neurologie, Frankfurt am Main, Deutschland
  • Christof Geisen - Institut für Transfusionsmedizin und Immunhämatologie, Immunhämatologie und Molekulare Hämostaseologie, Frankfurt am Main, Deutschland
  • Kolja Jahnke - Universitätsklinikum Frankfurt, Klinik für Neurologie, Frankfurt am Main, Deutschland
  • Volker Seifert - Universitätsklinikum Frankfurt, Klinik für Neurologie, Frankfurt am Main, Deutschland
  • Jürgen Konczalla - Universitätsklinikum Frankfurt, Klinik für Neurochirurgie, Frankfurt am Main, Deutschland
  • Christian Senft - Universitätsklinikum Frankfurt, Klinik für Neurologie, Frankfurt am Main, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie. Würzburg, 12.-15.05.2019. Düsseldorf: German Medical Science GMS Publishing House; 2019. DocV064

doi: 10.3205/19dgnc079, urn:nbn:de:0183-19dgnc0793

Published: May 8, 2019

© 2019 Dubinski et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

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Objective: Pulmonary embolism due to deep vein thrombosis is a complication with severe morbidity and mortality rates among neurointensive care patients. However, non-O blood type is associated with several thromboembolic events due to a different pro-coagulatory protein level. Neurocritical care patients constitute an inhomogeneous cohort with often several contraindications to conventional embolism treatment. The impact of blood type on pulmonary embolism rate in neurocritical patients remains elusive and prompted this study

Methods: In this retrospective analysis 387 neurocritical care patients received computed tomography for the suspected diagnosis of pulmonary embolism (304 neurosurgical and 83 neurological cases). Analyzed parameters included the presence of deep vein thrombosis, resuscitation, in hospital mortality, present anticoagulation, coronary heart disease, diabetes mellitus, hypertension and antidepressants.

Results: Computed tomography confirmed 165 cases of pulmonary embolism among 387 patients with suspected pulmonary embolism (42%). Younger age was a strong predictor of PE (p<0.0001). ABO blood was not significantly associated with deep vein thrombosis (p>0.05) but non-O blood type was highly associated with the risk of pulmonary embolism (p<0.005).

Conclusion: Non-O blood type is an inherited risk factor for pulmonary embolism among neurointensive care patients. Therefore, younger non-O blood type patients should have intensified monitoring for cardiovascular events in neurointensive care units.