gms | German Medical Science

70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

12.05. - 15.05.2019, Würzburg

Article

Send article

The Peripheral-Nerve-Tumor-Registry – study design, current state and preliminary retrospective two-year analysis

Das Periphere-Nerventumor-Register – Studiendesign, aktueller Stand und vorläufige retrospektive 2-Jahresanalyse

Meeting Abstract

Search Medline for

  • presenting/speaker Nora Dengler - Charité – Universitätsmedizin Berlin, Klinik für Neurochirurgie, Berlin, Deutschland
  • Gregor Antoniadis - BKH Günzburg an der Universität Ulm, Sektion Periphere Nerven, Klinik für Neurochirurgie, Günzburg, Deutschland
  • Ralph König - BKH Günzburg an der Universität Ulm, Sektion Periphere Nerven, Klinik für Neurochirurgie, Günzburg, Deutschland
  • Thomas Dombert - Praxis für Periphere Neurochirurgie, Dossenheim, Deutschland
  • Christian Heinen - BKH Günzburg an der Universität Ulm, Sektion Periphere Nerven, Klinik für Neurochirurgie, Günzburg, Deutschland; Universitätsklinik Oldenburg, Evangelisches Krankenhaus Oldenburg, Klinik für Neurochirurgie, Oldenburg, Deutschland
  • Christian Rainer Wirtz - BKH Günzburg an der Universität Ulm, Sektion Periphere Nerven, Klinik für Neurochirurgie, Günzburg, Deutschland
  • Peter Vajkoczy - Charité – Universitätsmedizin Berlin, Klinik für Neurochirurgie, Berlin, Deutschland
  • Maria Teresa Pedro - BKH Günzburg an der Universität Ulm, Sektion Periphere Nerven, Klinik für Neurochirurgie, Günzburg, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie. Würzburg, 12.-15.05.2019. Düsseldorf: German Medical Science GMS Publishing House; 2019. DocV051

doi: 10.3205/19dgnc066, urn:nbn:de:0183-19dgnc0662

Published: May 8, 2019

© 2019 Dengler et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

Text

Objective: Since clinical trial evidence on peripheral nerve tumors (PNT) is scarce, no uniform treatment recommendations exist. Acknowledging the need for dedicated health services research on PNT, the PNT-Registry was initiated in 2017 to fill this relative blind spot in the literature. The main goal is to document current treatment strategies and the clinical course of PNT in a multicenter setup. We here present the study design, current state of the project as well as a preliminary retrospective data-collection on PNT surgery.

Methods: The PNT-Registry is a multicenter observational study with retrospective and prospective patient enrollment. Patients diagnosed with a tumor in association to a peripheral nerve are included. Clinical variables including new neurological deficits, tumor recurrence and pain as well as surgical strategies, histology and perioperative imaging are analyzed. Patient enrollment is under way at 3 centers and 7 further centers are currently applying for approval at their local ethics committees.

Results: Preliminary retrospective patient data (n=104) of three high volume centers showed a predominance of benign lesions in association to peripheral nerves (50% schwannoma, 19% neurofibroma and 19% miscellaneous). Malign tumors were only rarely detected (12%) and include malign peripheral nerve sheath tumors, Ewing sarcoma, fibromyxosarcoma and carcinoma metastases. 12% of patients with neurofibromatosis I were included.

Conclusion: Already at this early stage, the multi-center PNT-Registry is providing data on rare peripheral nerve lesions. Currently, the inclusion rate of patients with neurofibromatosis I is relatively low, compared to existing patient series in the literature. The upcoming recruitment phase at 7 additional centers will help improve the spectrum of PNTs in the registry.