Article
Aneurysmal subarachnoid hemorrhage lead to elevated systemic levels of proinflammatory cytokine IL-23
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Published: | June 9, 2017 |
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Objective: IL-23 is a pro-inflammatory cytokine secreted by activated macrophages and dendritic cells. Serum IL-23 is increased in numerous inflammatory diseases including neurodegenrative diseases. The role of serum IL-23 has still not been investigated in aneurysmal subarachnoid hemorrhage (aSAH). The present work investigates the serum IL-23 and its association with post hemorrhagic complications in patients with aSAH.
Methods: 69 patients with aSAH (Hunt and Hess grade I-V) were prospectively recruited in this study. We enrolled 23 control patients with lumbar spinal stenosis. Peripheral venous blood was withdrawn from controls and aSAH patients at day 1 and day 7, allowed to clot and centrifuged to obtain serum. A standard enzyme linked immunoassay kit was employed to determine the serum levels of IL-23 by applying 50 µL of serum samples on the microwell plate. Post hemorrhagic complication and patient’s data were recorded prospectively.
Results: Serum IL-23 levels were significantly elevated in aSAH patients at day 1 (p = 0.03) and day 7 (p = 0.036) as compared to control patients. Further analysis after dichotomy of patients who suffered from post hemorrhagic complications including cerebral vasospasm, chronic hydrocephalus, seizures, cerebral ischemia, delayed neurological deficits did not differ in serum IL-23 levels as compared to patients without post hemorrhagic complications. Serum IL-23 levels did not correlate with clinical outcome.
Conclusion: Serum IL-23 was elevated in patients with aSAH showing upregulation of inflammatory immune response after aSAH. Serum IL-23 levels did not correlate with post hemorrhagic complications and clinical outcome.