gms | German Medical Science

68th Annual Meeting of the German Society of Neurosurgery (DGNC)
7th Joint Meeting with the British Neurosurgical Society (SBNS)

German Society of Neurosurgery (DGNC)

14 - 17 May 2017, Magdeburg

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Deep Brain Stimulation of the subthalamic nucleus improves sensorimotor gating in patients with idiopathic Parkinson’s disease

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  • Jared Schuster - Department of Stereotactic Neurosurgery, University Hospital of Magdeburg, Magdeburg, Deutschland
  • Imke Galazky - Universität Magdeburg, Neurologie, Magdeburg, Deutschland
  • Jürgen Voges - Universitätsklinikum Magdeburg, Klinik für Stereotaktische Neurochirurgie, Magdeburg, Deutschland
  • Hans-Jochen Heinze - Universitätsklinikum Magdeburg, Klinik für Neurologie, Leibniz Institut für Neurobiologie, Deutsches Zentrum für Neurodegenerative Erkrankungen, Magdeburg, Deutschland
  • Kupsch Andreas - Academic Neurology Practice, Berlin, Deutschland
  • Zaehle Tino - Universitätsklinikum Magdeburg, Klinik für Neurologie, Magdeburg, Deutschland
  • Patricia Panther - Universitätsklinikum Magdeburg, Klinik für Stereotaktische Neurochirurgie, Magdeburg, Deutschland

Deutsche Gesellschaft für Neurochirurgie. Society of British Neurological Surgeons. 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS). Magdeburg, 14.-17.05.2017. Düsseldorf: German Medical Science GMS Publishing House; 2017. DocP 162

doi: 10.3205/17dgnc725, urn:nbn:de:0183-17dgnc7259

Published: June 9, 2017

© 2017 Schuster et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

Text

Objective: Deep Brain Stimulation (DBS) of the subthalamic nucleus (STN) is known to improve motor symptoms and quality of life in patients suffering from idiopathic Parkinson's disease. The exact mechanisms of how STN-DBS affects neuronal network activity are not well understood. Prepulse inhibition (PPI) of acoustic startle describes an operational measure of the pre-attentive filtering process known as sensorimotor gating. Alterations in PPI indicate disturbances in network activity as found in neuropsychiatric disorders like Parkinson’s disease. In the present clinical study we investigated the effects of STN-DBS on PPI in patients with idiopathic Parkinson's disease.

Methods: Eight patients with idiopathic Parkinson’s disease and STN-DBS were investigated three months after implantation of electrodes. The medication was stopped 12h before testing. PPI was tested under two conditions: no stimulation (Med-OFF/ Stim-OFF) and with the stimulation setting of the best UPDRS-III-result (Med-OFF/ Stim-ON). UPDRS measurement was conducted before PPI testing.

Results: DBS of the STN (Med-OFF/ Stim-ON) compared to no stimulation (Med-OFF/ Stim-OFF) significantly increased the PPI (t(7)=-2.4, p<.05).

Conclusion: STN-DBS positively influences PPI in patients with Parkinson’s disease. Therefore, PPI could represent an indicator how DBS modulates network activity. Our results render PPI measurment as a potential tool for disease- and target specific optimization of DBS settings independent of the examiner or the patient.