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68th Annual Meeting of the German Society of Neurosurgery (DGNC)
7th Joint Meeting with the British Neurosurgical Society (SBNS)

German Society of Neurosurgery (DGNC)

14 - 17 May 2017, Magdeburg

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Repurposing of the old sulfone antibiotic dapsone for the treatment of gliomas

Meeting Abstract

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  • Georg Karpel-Massler - Neurochirurgische Klinik der Universität Ulm, Ulm, Deutschland
  • Richard Kast - IIAIGC, Burlington, VT, United States
  • Xiao Yun Chen - Jiangsu University of Science and Technology, Zhenjiang City, Jiangsu, China
  • Christian Rainer Wirtz - Bezirkskrankenhaus Günzburg, Neurochirurgische Klinik der Universität Ulm, Günzburg, Deutschland
  • Marc-Eric Halatsch - Neurochirurgische Klinik der Universität Ulm, Ulm, Deutschland
  • Carsten Bolm - Institut für organische Chemie der Universität Aachen, Aachen, Deutschland

Deutsche Gesellschaft für Neurochirurgie. Society of British Neurological Surgeons. 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS). Magdeburg, 14.-17.05.2017. Düsseldorf: German Medical Science GMS Publishing House; 2017. DocP 033

doi: 10.3205/17dgnc596, urn:nbn:de:0183-17dgnc5966

Published: June 9, 2017

© 2017 Karpel-Massler et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

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Objective: Dapsone is an antibiotic used for the treatment of mycobacterial and protozoal infections. We previously hypothesized that dapsone could possess biological activity extending beyond its anti-infectious properties and that it potentially represents a candidate for repurposing in the setting of glioma therapy.

Methods: Established glioblastoma cell lines and primary cultured glioma cells were treated with dapsone or several different chemical analogues of dapsone which we previously synthesized (D2-D5) and examined effects on proliferation, anchorage-independent growth and migration.

Results: Dapsone and its synthetic analogues D2-D5 displayed only modest anti-proliferative activity. However, treatment with dapsone lead to a significant inhibition of important neoplastic features such as anchorage-independent growth and directed migration. Moreover, several dapsone analogues yielded even enhanced anti-glioma activity.

Conclusion: Dapsone has pronounced activity against glioma which can be further enhanced by its molecular modification. Overall, dapsone holds strong promise to serve as a supplementary therapeutic measure for glioma therapy in a repurposing approach.