gms | German Medical Science

68th Annual Meeting of the German Society of Neurosurgery (DGNC)
7th Joint Meeting with the British Neurosurgical Society (SBNS)

German Society of Neurosurgery (DGNC)

14 - 17 May 2017, Magdeburg

The human globus pallidus internus is sensitive to rewards – evidence from intracerebral recordings

Meeting Abstract

  • Thomas Münte - Lübeck, Deutschland
  • Josep Marco-Pallares - Barcelona, Spain
  • Seza Bolat - Lübeck, Deutschland
  • Marcus Heldmann - Lübeck, Deutschland
  • Götz Lütjens - Hannover, Deutschland
  • Wido Nager - Hamburg, Deutschland
  • Joachim K. Krauss - Medizinische Hochschule Hannover, Neurochirurgische Klinik, Klinik für Neurochirurgie, Hannover, Deutschland

Deutsche Gesellschaft für Neurochirurgie. Society of British Neurological Surgeons. 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS). Magdeburg, 14.-17.05.2017. Düsseldorf: German Medical Science GMS Publishing House; 2017. DocMi.06.08

doi: 10.3205/17dgnc401, urn:nbn:de:0183-17dgnc4018

Published: June 9, 2017

© 2017 Münte et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.


Outline

Text

Objective: The globus pallidus internus (GPi) is the final output relay of the basal ganglia for the control of movements but has also been shown to belong to a second pathway projecting to the lateral habenula. This latter pathway is related to reward processing. This prompted us to record, in eight patients receiving deep brain stimulation of the GPI for the alleviation of movement disorders, local field potentials while these patients performed a lottery task.

Methods: The task entailed choosing between a higher and a lower number, which changed their color after the patient’s choice with red (green) signaling a loss (win, in Euro cents) corresponding to the chosen number.

Results: Surface recordings showed a feedback related negativity from a frontal midline site, while time domain averages in the GPI showed differential modulation depending on the valence of the stimulus with polarity inversion indicating that this reward-modulated activity was indeed generated locally. Furthermore, wavelet decomposition of the LFP showed a reward-related response in the high beta / low gamma range.

Conclusion: We conclude that human GPI is involved in reward processing, possibly in relation to the lateral habenula.