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68th Annual Meeting of the German Society of Neurosurgery (DGNC)
7th Joint Meeting with the British Neurosurgical Society (SBNS)

German Society of Neurosurgery (DGNC)

14 - 17 May 2017, Magdeburg

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WHO grade of intracranial meningiomas differ with respect to patient age and Tumor location

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  • Anne Wallrodt - Neurochirurgie, Helios Klinikum Erfurt, Erfurt, Deutschland
  • Michael Brodhun - Institut für Pathologie, Helios Klinikum Erfurt, Erfurt, Deutschland
  • Steffen Rosahl - HELIOS Klinikum Erfurt, Klinik für Neurochirurgie, Erfurt, Deutschland
  • Rüdiger Gerlach - Helios Klinikum Erfurt, Erfurt, Deutschland

Deutsche Gesellschaft für Neurochirurgie. Society of British Neurological Surgeons. 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS). Magdeburg, 14.-17.05.2017. Düsseldorf: German Medical Science GMS Publishing House; 2017. DocDI.18.07

doi: 10.3205/17dgnc284, urn:nbn:de:0183-17dgnc2842

Published: June 9, 2017

© 2017 Wallrodt et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

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Objective: Patients with WHO grade I and II intracranial meningiomas differ with respect to recurrence rate and overall survival. We aimed to investigate the relationship of patient age and meningioma location on the WHO grade.

Methods: A single institution data base of consecutive operated patients with intracranial meningiomas (January 2007 – March 2013) was reviewed. Patient characteristics, histological diagnosis (WHO 2007 classification), tumor location and size (MRI), outcome (mRS) and recurrence rates were analyzed retrospectively. Age was grouped into 3 different categories; group 1 (20-40 years), group 2 (41-60 years) group 3 (61-84years).

Results: Of 240 patients 186 (77.5%) were female and 54 (22.5%) male. Mean age was not statistically different between female and male. 21 patients (8.8%) fell in age group I, 121 (50.4%) in group II, and 98 (40.8%) fell in age group III. 187 patients (77.5%) harbored a WHO °I, 50 (20.4%) a WHO °II, and 5 (2.1%) a WHO °III meningioma. Grading did not differ significantly between female and male patients (א²(2,N=240)=1,09, p=0,62). WHO °II and °III meningiomas were significantly more frequent in age group I compared to age group II (א²(2 N=142)11,00 p=0,004), but did not differ between groups II and III, or I and III. Convexity meningiomas were significantly more frequent classified as WHO°II meningioma compared to all other locations (א²(2, N=240)=19,83, p=0,000). Short term outcome did not differ between age groups nor was it associated with tumor size. Recurrence rate was significantly higher in WHO° II (5 out of47, 10.2%) compared to WHO °I patients (1 out if 178, 0.6%, p<0.05).

Conclusion: Younger patients suffer more frequently from WHO°II meningiomas. Meningiomas located at the convexity are more likely to be classified as WHO °II tumors.