Article
Intensive Insulin therapy in patients with severe head injury; role and possible effects
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Published: | June 9, 2017 |
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Objective: The role of Intensive Insulin Therapy (IIT) in patients with neurotrauma is unclear. Purpose of this study was to evaluate the effects of intensive insulin therapy in patients with severe head injury especially possible effects of intracranial pressure.
Methods: It was a single center non randomized study. Patients with intensive insulin therapy were prospective evaluated (IITG) und compared with patients of a historical controlgroup where only strong hyperglycemia (>10 mmol/l) was treated (CTG). Patients of both groups were matched for statistical analysis. Blood glucose levels and ICP-levels were registered over the time and shown as an Area under the Curve (AUC). SAPS II-Score, number of decompressive craniectomies, duration of ventilation, duration until oral feeding, duration on ICU, rates of infection, GOS and mRS were analyzed and compared.
Results: 130 patients were included, thus 65 patients of each group were matched. Rates of infection and duration until oral feeding were significant better in the IITG. The ICP-courses, number of decompressive craniectomies and GOS / mRS showed a positive trend in the IITG. Furthermore patients with an initial better neurologic score showed significant worse ICU-courses in case of hyperglycemia.
Conclusion: Intensive insulin therapy might have positiv effects in patients with severe head injury. Especially the ICP-courses and patients with an initial better neurologic state seem to profit from intensive insulin therapy. Further evaluation should be initiated.