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68th Annual Meeting of the German Society of Neurosurgery (DGNC)
7th Joint Meeting with the British Neurosurgical Society (SBNS)

German Society of Neurosurgery (DGNC)

14 - 17 May 2017, Magdeburg

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Impact of anesthetic technique on recurrence and outcome in patients with glioblastoma

Meeting Abstract

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  • Stephanie Kellermann - Uniklinik Köln, Klinik für Allgemeine Neurochirurgie, Zentrum für Neurochirurgie, Uniklinik Köln, Köln, Deutschland
  • Valeria Taurisano - Klinik für Anästhesiologie und Operative Intensivmedizin, Uniklinik Köln, Köln, Deutschland
  • Marco Timmer - Uniklinik Köln, Klinik für Allgemeine Neurochirurgie, Zentrum für Neurochirurgie, Uniklinik Köln, Köln, Deutschland
  • Roland Goldbrunner - Uniklinik Köln, Klinik für Allgemeine Neurochirurgie, Zentrum für Neurochirurgie, Uniklinik Köln, Köln, Deutschland
  • Thorsten Annecke - Klinik für Anästhesiologie und Operative Intensivmedizin, Uniklinik Köln, Köln, Deutschland
  • Stefan Grau - Uniklinik Köln, Klinik für Allgemeine Neurochirurgie, Zentrum für Neurochirurgie, Uniklinik Köln, Köln, Deutschland

Deutsche Gesellschaft für Neurochirurgie. Society of British Neurological Surgeons. 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS). Magdeburg, 14.-17.05.2017. Düsseldorf: German Medical Science GMS Publishing House; 2017. DocMO.22.05

doi: 10.3205/17dgnc132, urn:nbn:de:0183-17dgnc1323

Published: June 9, 2017

© 2017 Kellermann et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

Text

Objective: Perioperative administration of volatile anesthetics or opioids is known to impair humoral and cellular immune function and latest studies suggest an influence on recurrence rates in patients with solid tumors. We investigated the potential influence of the anesthetic method on progression-free (PFS) and overall survival (OS) in patients with glioblastoma.

Methods: In a retrospective single-center analysis we identified all adult patients undergoing complete resection of contrast enhancing glioblastoma under general anesthesia followed by standard radio-chemotherapy. We then formed two matched groups differing in anesthetic technique only, including volatile anesthetics (VA) versus total-intravenous anesthesia (TIVA). Outcome measures were PFS and OS. Groups were compared using chi square, Mann-Whitney U-test and Kaplan-Meier method for survival estimates.

Results: A total of 120 patients were included, balanced with 60 patients in each anesthesia-method group. There was no significant difference regarding age, preoperative KPS, MGMT promotor methylation, IDH mutation status and extent of resection. Choice of the anesthetic drug did not influence time to progression (p=0.879) nor OS (p=0.324).

Conclusion: There appears to be no impact of the choice of the anesthetic drug on recurrence and overall survival in patients with glioblastoma.