gms | German Medical Science

68th Annual Meeting of the German Society of Neurosurgery (DGNC)
7th Joint Meeting with the British Neurosurgical Society (SBNS)

German Society of Neurosurgery (DGNC)

14 - 17 May 2017, Magdeburg

Prognostic value of S100B protein and neuron-specific enolase in patients with poor grade aneurysmal subarachnoid haemorrhage

Meeting Abstract

  • Tammam Abboud - Neurochirurgische Klinik, UKE, Hamburg, Deutschland
  • Christian Mende - Universitätsklinikum Hamburg Eppendorf, Klinik für Neurochirurgie, Hamburg, Deutschland
  • Roman Jung - HAmburg, Deutschland
  • Patrick Czorlich - Universitätsklinikum Hamburg-Eppendorf, Klinik und Poliklinik für Neurochirurgie, Hamburg, Deutschland
  • Eik Vettorazzi - Hamburg, Deutschland
  • Marion Priefler - Hamburg, Deutschland
  • Stefan Kluge - Klinik für Intensivmedizin, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland
  • Manfred Westphal - Universitätsklinikum Hamburg-Eppendorf, Klinik und Poliklinik für Neurochirurgie, Hamburg, Deutschland
  • Jan Regelsberger - HAmburg, Deutschland

Deutsche Gesellschaft für Neurochirurgie. Society of British Neurological Surgeons. 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS). Magdeburg, 14.-17.05.2017. Düsseldorf: German Medical Science GMS Publishing House; 2017. DocMO.08.02

doi: 10.3205/17dgnc043, urn:nbn:de:0183-17dgnc0430

Published: June 9, 2017

© 2017 Abboud et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.


Outline

Text

Objective: To investigate the value of S100b protein (S100) and neuron-specific enolase (NSE) in prognosticating outcome in patients with high grade aneurysmal subarachnoid haemorrhage (SAH).

Methods: Between 2012- 2014, patients SAH (Hunt & Hess grade 3-5) who were admitted within 24 hours after haemorrhage were prospectively enrolled. Serum NSE and S100 levels were assayed once daily during the first 3 days after haemorrhage. Patient characteristics, Glasgow Coma Scale, Hunt & Hess and Fisher grade at admission were recorded. Glasgow outcome scale was obtained at 6 months and dichotomized as poor (1–3) or good (4–5). Logistic regression and ROC curve were used to assess the predictive value of S100 and NSE and cut-off values were calculated using conditional interference trees.

Results: 52 patients were included. Hunt & Hess grading was 3 in 23 patients, 4 in 15 and 5 in 14 patients. S100 ranged from 0.07 to 5.62µg/l (mean 0.87±1.06µg/l). NSE range was 5.7 to 94.2µg/l (mean of 16.1±10.5µg/l). At 6 months follow-up, 23 patients (44.2%) had poor outcome and 29 (55.8%) showed good outcome. Both S100 at day one (p=0.004, cut-off 0.202µg/l) and NSE at day one (p=0.047, cut-off 9.4µg/l) predicted good outcome with a specificity of 100%. The specificity of mean S100 in predicting poor outcome reached 100% (p=0.003) when combined with mean NSE levels.

Conclusion: S100 and NSE measured during the first 3 days after haemorrhage showed separately and combined a significant predictive value in prognosticating clinical outcome in patients with high grade SAH.