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66th Annual Meeting of the German Society of Neurosurgery (DGNC)
Friendship Meeting with the Italian Society of Neurosurgery (SINch)

German Society of Neurosurgery (DGNC)

7 - 10 June 2015, Karlsruhe

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Event-related potentials in the bed nucleus of the stria terminalis/ internal capsule in response to neutral and aversive stimuli in OCD

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  • Götz Lütjens - Klinik für Neurochirurgie, Medizinische Hochschule Hannover, Hannover
  • Lotta Winter - Klinik für Psychiatrie, Sozialpsychiatrie und Psychotherapie, Medizinische Hochschule Hannover, Hannover
  • Alam Mesbah - Klinik für Neurochirurgie, Medizinische Hochschule Hannover, Hannover
  • Kerstin Schwabe - Klinik für Neurochirurgie, Medizinische Hochschule Hannover, Hannover
  • Kai Kahl - Klinik für Psychiatrie, Sozialpsychiatrie und Psychotherapie, Medizinische Hochschule Hannover, Hannover
  • Joachim K. Krauss - Klinik für Neurochirurgie, Medizinische Hochschule Hannover, Hannover

Deutsche Gesellschaft für Neurochirurgie. 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC). Karlsruhe, 07.-10.06.2015. Düsseldorf: German Medical Science GMS Publishing House; 2015. DocP 104

doi: 10.3205/15dgnc502, urn:nbn:de:0183-15dgnc5025

Published: June 2, 2015

© 2015 Lütjens et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

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Objective: Deep brain stimulation (DBS) is an innovative therapy for patients with treatment refractory obsessive compulsive disorders (trOCD), aiming at the normalisation of abnormal activity in cortico-striato-thalamo-cortical circuits. The present study aims to characterize the evoked related potentials (ERPs) measured during natural and aversive visual stimuli in the bed nucleus of the stria terminalis/ internal capsule (BNST/IC) in patient with obsessive-compulsive disorder (OCD), and the effects of metacognitive therapy (MCT) thereof. MCT belongs to the most recent developments in cognitive behavioural therapy.

Method: Evoked related potentials (ERPs) were directly recorded via electrodes implanted for DBS in the BNST in one patient with trOCD while viewing neutral and aversive pictures. Thereafter, intensive MCT was applied for four days. Finally, neutral and aversive pictures were shown and assessment of ERPs was done as described before with using the latency of P300 as measure.

Results: Before therapy the latency of P300 was reduced after aversive stimuli as compared to neutral stimuli (p<0.05), while after MCT, the latency was enhanced (p<0.05).

Conclusions: We show that the neuronal response of BNST differs between neutral and aversive pictures in OCD, and that MCT has an impact on this neuronal response. These results suggest that the BNST/IC is involved in sensory and cognitive information processing in OCD.