gms | German Medical Science

64th Annual Meeting of the German Society of Neurosurgery (DGNC)

German Society of Neurosurgery (DGNC)

26 - 29 May 2013, Düsseldorf

Influence of VEGFR and Aquaporin4 in peritumoral brain edema in meningiomas

Meeting Abstract

  • Stefan Linsler - Neurochirurgie, Universitätskliniken des Saarlandes, Homburg/Saar, Deutschland
  • David Reuss - Abteilung für Neuropathologie, Universitätsklinikum Heidelberg, Heidelberg, Deutschland
  • Steffi Urbschat - Neurochirurgie, Universitätskliniken des Saarlandes, Homburg/Saar, Deutschland
  • Markus Klotz - Universität für angewandte Wissenschaften, Fachhochschule Kaiserslautern, Mikrosystemtechnik, Zweibrücken, Deutschland
  • Ralf Ketter - Neurochirurgie, Universitätskliniken des Saarlandes, Homburg/Saar, Deutschland
  • Joachim Oertel - Neurochirurgie, Universitätskliniken des Saarlandes, Homburg/Saar, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC). Düsseldorf, 26.-29.05.2013. Düsseldorf: German Medical Science GMS Publishing House; 2013. DocP 137

doi: 10.3205/13dgnc554, urn:nbn:de:0183-13dgnc5547

Published: May 21, 2013

© 2013 Linsler et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Objective: It is well known that VEGFR expression is correlated with peritumoral brain edema in meningiomas. Also Aquaporin4 seems to induce the perifocal edema. In our study we analyzed the correlation of VEGFR1, VEGFR2 and Aquaporin4 to the brain edema. Additionally a potential correlation between the typical chromosomal deletions in meningiomas and the expression of VEGFR and Aquaporin4 was evaluated.

Method: Tissue specimens of 77 meningioma patients were obtained from surgery between 2009 and 2010. FISH analysis using the locus specific probes detecting the chromosomes 1, 9, 14, 18 and 22 were performed. Also immunoblotting were performed to detect the expression of VEGFR1 and VEGFR2. Aquaporin4 was detected by ELISA. The results were correlated to the FISH results and the peritumoral brain edema in the preoperative MRI. The peritumoral edema was calculated on T2-weighted or FLAIR images. Statistical analysis including correlation and Mann-Withney U-Test was performed.

Results: In the present study was revealed a significant correlation of VEGFR2 to the brain edema in the meningiomas (p<0.01). However there was found no significant correlation of VEGFR1 and the brain edema. Also Aquaporin4 had no significant impact of the brain edema in meningiomas. The analyzed – progression associated – chromosomal aberrations of 1,9,14,18 and 22 had no correlation to the expression of VEGFR1, VEGFR2 and Aquaporin4, respectively.

Conclusions: We were able to confirm previous results of a high correlation of VEGFR2-expression to the formation of a peritumoral brain edema. Interestingly VEGFR 1 and also Aquaporin4 did not influence the extent of brain edema in our series. The expression of VEGFR1, of VEGFR2 and also of Aquaporin4 did not correlate with any specific chromosomal aberrations in meningiomas and histological grading. Still not all factors which induce a peritumoral brain edema in meningiomas are clear. Therefore, in addition to gene and protein expression anatomical conditions should be account in each individual patient.