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64th Annual Meeting of the German Society of Neurosurgery (DGNC)

German Society of Neurosurgery (DGNC)

26 - 29 May 2013, Düsseldorf

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Calcifying pseudoneoplasms of the neuraxis (CAPNON): meta-analysis of all published intracranial cases

Meeting Abstract

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  • Martin N. Stienen - Clinic for Neurosurgery, Kantonsspital St.Gallen, St.Gallen, Switzerland
  • Amr N. Abdulazim - Department of Neuroanatomy and Molecular Brain Research, Ruhr-University Bochum, Bochum, Germany
  • Oliver P. Gautschi - Department of Neurosurgery, Geneva University Medical Center, University of Geneva, Geneva, Switzerland
  • T. Marcel Schneiderhan - Department of Neuropathology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
  • Gerhard Hildebrandt - Clinic for Neurosurgery, Kantonsspital St.Gallen, St.Gallen, Switzerland
  • Sebastian Lücke - Department of Neurosurgery, Knappschafts Hospital Langendreer, Ruhr-University Bochum, Bochum, Germany

Deutsche Gesellschaft für Neurochirurgie. 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC). Düsseldorf, 26.-29.05.2013. Düsseldorf: German Medical Science GMS Publishing House; 2013. DocP 088

doi: 10.3205/13dgnc505, urn:nbn:de:0183-13dgnc5053

Published: May 21, 2013

© 2013 Stienen et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Objective: Calcifying pseudoneoplasms of the neuraxis (CAPNON) are rare, benign tumours of the central nervous system (CNS). Since their initial description in 1978, only 20 intracranial cases have been reported in case reports or case series.

Method: We report two further cases with histopathologically verified diagnosis of CAPNON. In addition, a meta-analysis of all so far published cases is provided. Here, study type, anatomical area, clinical presentation, radiological presentation, therapy, duration of follow-up, incidence and type of complication, and outcome are analysed. We then discuss current recommendations for the management of intracranial CAPNON.

Results: Adding our two patients, a total of 22 patients with intracranial CAPNON were analysed. All patients were treated surgically. For 16 patients with intracranial CAPNON (72.7%) follow-up was provided in the original reports. In 15 of 16 patients with intracranial CAPNON (93.7%) no sign of tumour recurrence was observed at the time of the follow-up. One-tailed Fisher's exact test revealed no significant difference between complete and incomplete resection in terms of disease recurrence (p=0.3749). No death was directly associated with CAPNON.

Conclusions: Calcifying pseudoneoplasms are rare slow growing, possibly reactive lesions of the CNS of yet unknown origin. CAPNON should be taken into consideration in the differential diagnosis of intracranial calcified lesions, as an increasingly number of publications report CAPNON as underlying pathology.