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64th Annual Meeting of the German Society of Neurosurgery (DGNC)

German Society of Neurosurgery (DGNC)

26 - 29 May 2013, Düsseldorf

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Sequential changes in neuronal activity in single neocortical neurons after spreading depression

Meeting Abstract

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  • Maryam Khaleghi Ghadiri - Klinik und Poliklinik für Neurochirurgie, Universitätsklinikum Münster, Münster, Deutschland
  • M. Kozian - Klinik und Poliklinik für Neurochirurgie, Universitätsklinikum Münster, Münster, Deutschland
  • N. Ghaffarian - Klinik und Poliklinik für Neurochirurgie, Universitätsklinikum Münster, Münster, Deutschland
  • Walter Stummer - Klinik und Poliklinik für Neurochirurgie, Universitätsklinikum Münster, Münster, Deutschland
  • Erwin-J. Speckmann - Klinik und Poliklinik für Neurochirurgie, Universitätsklinikum Münster, Münster, Deutschland
  • Ali Gorji - Klinik und Poliklinik für Neurochirurgie, Universitätsklinikum Münster, Münster, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC). Düsseldorf, 26.-29.05.2013. Düsseldorf: German Medical Science GMS Publishing House; 2013. DocP 072

doi: 10.3205/13dgnc489, urn:nbn:de:0183-13dgnc4890

Published: May 21, 2013

© 2013 Khaleghi Ghadiri et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Objective: Cortical spreading depression (CSD) has an important role in cerebrovascular disorders as well as migraine with aura. Prolonged neuronal depression is followed by a late excitatory synaptic plasticity after CSD.

Method: Intra- and extracellular recordings were performed to investigate the effect of CSD on intracellular properties of mouse neocortical tissues in the late excitatory period.

Results: During CSD, changes in the membrane potentials usually began with a relatively short hyperpolarization followed by an abrupt depolarization. These changes occurred roughly at the same time point after CSD as the beginning of the negative extracellular deflection. Forty-five minutes after CSD, neurons showed significantly smaller amplitude of afterhyperpolarization and a reduced input resistance. Depolarization and hyperpolarization of the cells by constant intracellular current injections in this period significantly changed the frequency of the action potentials.

Conclusions: These data indicate higher excitability of the neocortical neurons after CSD, which can be assumed to contribute to hyperexcitability of neocortical tissues in patients suffering from migraine.