gms | German Medical Science

64th Annual Meeting of the German Society of Neurosurgery (DGNC)

German Society of Neurosurgery (DGNC)

26 - 29 May 2013, Düsseldorf

Copeptin as a marker for severity and prognosis of aneurysmal subarachnoid hemorrhage

Meeting Abstract

  • Christian Fung - Universitätsklinik für Neurochirurgie, Inselspital, Bern, Schweiz
  • Gian Marco De Marchis - Universitätsklinik für Neurologie, Inselspital, Bern, Schweiz
  • Mira Katan - Universitätsspital Basel, Universitätsklinik für Neurologie, Basel, Schweiz
  • Marleen Seiler - Thermo Fisher Scientific, Thermo Scientific Biomarkers, Clinical Diagnostics, Henningsdorf
  • Andreas Raabe - Universitätsklinik für Neurochirurgie, Inselspital, Bern, Schweiz
  • Jürgen Beck - Universitätsklinik für Neurochirurgie, Inselspital, Bern, Schweiz

Deutsche Gesellschaft für Neurochirurgie. 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC). Düsseldorf, 26.-29.05.2013. Düsseldorf: German Medical Science GMS Publishing House; 2013. DocP 058

doi: 10.3205/13dgnc475, urn:nbn:de:0183-13dgnc4753

Published: May 21, 2013

© 2013 Fung et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Objective: Grading of patients with aneurysmal subarachnoid hemorrhage (aSAH) is often confounded by seizure, hydrocephalus or sedation and the prediction of prognosis remains difficult. Recently, copeptin has been identified as a serum marker for outcomes in acute ischemic stroke and intracerebral hemorrhage (ICH). We investigated whether copeptin might serve as a marker for severity and prognosis in aSAH.

Method: Eighteen consecutive patients with aSAH had plasma copeptin levels measured with a validated chemiluminescence sandwich immunoassay. The primary endpoint was the association of copeptin levels at admission with the World Federation of Neurological Surgeons (WFNS) grade score after resuscitation. Levels of copeptin were compared across clinical and radiological scores as well as between patients with ICH, intraventricular hemorrhage, hydrocephalus, vasospasm and ischemia.

Results: Copeptin levels were significantly associated with the severity of aSAH measured by WFNS grade (P=0.006), the amount of subarachnoid blood (P=0.03) and the occurrence of ICH (P=0.02). There was also a trend between copeptin levels and functional clinical outcome at 6-months (P=0.054). No other clinical outcomes showed any statistically significant association

Conclusions: Copeptin may indicate clinical severity of the initial bleeding and may therefore help in guiding treatment decisions in the setting of aSAH. These initial results show that copeptin might also have prognostic value for clinical outcome in aSAH.