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64th Annual Meeting of the German Society of Neurosurgery (DGNC)

German Society of Neurosurgery (DGNC)

26 - 29 May 2013, Düsseldorf

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FoxM1 promotes β-Catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis

Meeting Abstract

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  • Nu Zhang - Department of Neurosurgery, Shanghai Cancer Center, Fudan University, Shanghai, China
  • Ping Wei - Department of Neurosurgery, Shanghai Cancer Center, Fudan University, Shanghai, China; Institutes of Biomedical Sciences, Shanghai Cancer Center, Fudan University, Shanghai, China
  • Aihua Gong - Department of Neurosurgery, Shanghai Cancer Center, Fudan University, Shanghai, China
  • Wen-Tai Chiu - Department of Neurosurgery, Shanghai Cancer Center, Fudan University, Shanghai, China
  • Hsueh-Te Lee - Department of Neurosurgery, Shanghai Cancer Center, Fudan University, Shanghai, China
  • Howard Colman - Department of Neuro-Oncology, Shanghai Cancer Center, Fudan University, Shanghai, China
  • He Huang - F.M. Kirby Neurobiology Center, Children’s Hospital Boston, Harvard Medical School, Boston, USA
  • Jianfei Xue - Department of Neurosurgery, The University of Texas, M.D. Anderson Cancer Center, Houston, USA
  • Mingguang Liu - Department of Neurosurgery, The University of Texas, M.D. Anderson Cancer Center, Houston, USA
  • Yong Wang - Department of Neurosurgery, The University of Texas, M.D. Anderson Cancer Center, Houston, USA
  • Raymond Sawaya - Department of Neurosurgery, The University of Texas, M.D. Anderson Cancer Center, Houston, USA
  • Keping Xie - Department of Gastrointestinal Medical Oncology, The University of Texas, M.D. Anderson Cancer Center, Houston, USA; Program in Cancer Biology, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, USA
  • W. K. Alfred Yung - Department of Neuro-Oncology, The University of Texas, M.D. Anderson Cancer Center, Houston, USA
  • René H. Medema - Department of Medical Oncology, UMC Utrecht, Utrecht, The Netherlands
  • Xi He - F.M. Kirby Neurobiology Center, Children’s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA Correspondence: suhuang@mdanderson.org
  • Suyun Huang - Department of Neurosurgery, Shanghai Cancer Center, Fudan University, Shanghai, China; Program in Cancer Biology, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston TX, USA

Deutsche Gesellschaft für Neurochirurgie. 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC). Düsseldorf, 26.-29.05.2013. Düsseldorf: German Medical Science GMS Publishing House; 2013. DocMO.17.07

doi: 10.3205/13dgnc153, urn:nbn:de:0183-13dgnc1530

Published: May 21, 2013

© 2013 Zhang et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Wnt/β-catenin signaling is essential for stem cell regulation and tumorigenesis, but its molecular mechanisms are not fully understood. Here, we report that FoxM1 is a downstream component of Wnt signaling and is critical for β-catenin transcriptional function in tumor cells. Wnt3a increases the level and nuclear translocation of FoxM1, which binds directly to β-catenin and enhances β-catenin nuclear localization and transcriptional activity. Genetic deletion of FoxM1 in immortalized neural stem cells abolishes β-catenin nuclear localization. FoxM1 mutations that disrupt the FoxM1-β-catenin interaction or FoxM1 nuclear import prevent β-catenin nuclear accumulation in tumor cells. FoxM1-β-catenin interaction controls Wnt target gene expression, is required for glioma formation, and represents a mechanism for canonical Wnt signaling during tumorigenesis.