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60th Annual Meeting of the German Society of Neurosurgery (DGNC)
Joint Meeting with the Benelux countries and Bulgaria

German Society of Neurosurgery (DGNC)

24 - 27 May 2009, Münster

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Is surgical treatment a good option for recurrent gliblastoma multiforme?

Meeting Abstract

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  • P. Czochra - Neurochirurgische Klinik, Klinikum Stuttgart
  • M. Nadji-Ohl - Neurochirurgische Klinik, Klinikum Stuttgart
  • N. Hopf - Neurochirurgische Klinik, Klinikum Stuttgart

Deutsche Gesellschaft für Neurochirurgie. 60. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit den Benelux-Ländern und Bulgarien. Münster, 24.-27.05.2009. Düsseldorf: German Medical Science GMS Publishing House; 2009. DocMI.10-04

doi: 10.3205/09dgnc243, urn:nbn:de:0183-09dgnc2439

Published: May 20, 2009

© 2009 Czochra et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Objective: Several treatment options exist for recurrent glioblastoma patients, but there is no established standard therapy. In most cases, a change of the chemotherapy regime is recommended. Surgical treatment is thought to have a positive effect based on cytoreduction on overall survival or progress free survival. Therefore, we analyzed the indication and overall survival after second surgery for recurrent glioblastoma in a large series of patients.

Methods: We performed a retrospective statistical analysis of 248 consecutive patients, surgically treated at our department for glioblastoma from 2003 until 2007. The overall survival in patients with recurrent glioblastoma was compared for surgically and conservatively treated patients.

Results: Depending on the localization, configuration, Karnofsky performance index, age and informed consent, a second surgery was performed in only 13,5% of patients. The overall survival was significantly better (p<0.01) for surgically treated patients with 16 months (SD 7.03) compared to 8.8 months (SD 7.5). for patients treated with conservative measures.

Conclusions: In our series, surgery for recurrent tumors seems to be associated with prolonged survival. Patient selection may be a possible explanation for this finding. Further investigations will have to determine the role of surgery in patients with recurrent glioblastoma.