gms | German Medical Science

55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

25. bis 28.04.2004, Köln

The reliability of NMR-spectroscopic examination of low grade gliomas

Die Reliabilität der MR-spektroskopischen Untersuchung von niedriggradigen Gliomen

Meeting Abstract

  • corresponding author Senol Jadik - Klinik für Neurochirurgie des Universitätsklinikums Frankfurt, Frankfurt/Main
  • K. Franz - Klinik für Neurochirurgie des Universitätsklinikums Frankfurt, Frankfurt/Main
  • E. Hattingen - Kinik für Neuroradiologie des Universitätsklinikums Frankfurt, Frankfurt/Main
  • V. Seifert - Klinik für Neurochirurgie des Universitätsklinikums Frankfurt, Frankfurt/Main

Deutsche Gesellschaft für Neurochirurgie. Ungarische Gesellschaft für Neurochirurgie. 55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie. Köln, 25.-28.04.2004. Düsseldorf, Köln: German Medical Science; 2004. DocP 06.57

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dgnc2004/04dgnc0340.shtml

Published: April 23, 2004

© 2004 Jadik et al.
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Outline

Text

Objective

In the diagnosis of low grade gliomas, the NMR-spectroscopic examination plays an important role. We compared the spectroscopic examination with the histopathologic results of low grade gliomas concerning it's reliability.

Methods

The charts of 29 patients with low grade gliomas were collected. In 19 cases an NMR-spectroscopic examination was performed. Due to cholin, NAA and lipid content the gliomas were classified into astrocytoma WHO II or III or in low or high grade gliomas. After stereotactic biopsy or neurosurgical removal, histopathological examination was performed.

Results

We found 18 astrocytomas WHO II and 1 oligodendroglioma WHO II at the histopathological examination. In the spectroscopic examination we found 13 low grade gliomas II and 6 high grade gliomas. 68,4 % of the 29 low grade gliomas WHO II correspond to the spectroscopic examination. 6 cases showed high cholin contents and one of them with cholin content which would correspond to a glioblastoma. These tumors were classified as low grade gliomas WHO II in the histopathologic examination.

Conclusions

We compared the NMR-spectroscopic findings with the histopathologic results of the tumors. The actual spectroscopic method does not seems to be reliable enough in the diagnosis of low grade gliomas. Whether the NMR-spectroscopic findings correlate with the clinical course better than with the histopathologic findings remains to be clarified.