Artikel
The reliability of NMR-spectroscopic examination of low grade gliomas
Die Reliabilität der MR-spektroskopischen Untersuchung von niedriggradigen Gliomen
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Autoren
Veröffentlicht: | 23. April 2004 |
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Gliederung
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Objective
In the diagnosis of low grade gliomas, the NMR-spectroscopic examination plays an important role. We compared the spectroscopic examination with the histopathologic results of low grade gliomas concerning it's reliability.
Methods
The charts of 29 patients with low grade gliomas were collected. In 19 cases an NMR-spectroscopic examination was performed. Due to cholin, NAA and lipid content the gliomas were classified into astrocytoma WHO II or III or in low or high grade gliomas. After stereotactic biopsy or neurosurgical removal, histopathological examination was performed.
Results
We found 18 astrocytomas WHO II and 1 oligodendroglioma WHO II at the histopathological examination. In the spectroscopic examination we found 13 low grade gliomas II and 6 high grade gliomas. 68,4 % of the 29 low grade gliomas WHO II correspond to the spectroscopic examination. 6 cases showed high cholin contents and one of them with cholin content which would correspond to a glioblastoma. These tumors were classified as low grade gliomas WHO II in the histopathologic examination.
Conclusions
We compared the NMR-spectroscopic findings with the histopathologic results of the tumors. The actual spectroscopic method does not seems to be reliable enough in the diagnosis of low grade gliomas. Whether the NMR-spectroscopic findings correlate with the clinical course better than with the histopathologic findings remains to be clarified.