Artikel
Weight Loss and the Renin-Angiotensin-Aldosterone System
Gewichtsreduktion und das Renin-Angiotensin-Aldosteron System
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Autoren
Veröffentlicht: | 10. August 2005 |
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Gliederung
Text
The renin-angiotensin-aldosterone system (RAAS) has been causally implicated in obesity-associated hypertension. We studied the influence of obesity and weight reduction on the circulating and adipose tissue RAAS in menopausal women. Blood samples were analyzed for angiotensinogen (AGT), renin, aldosterone, angiotensin-converting enzyme (ACE) activity, and angiotensin II. In adipose tissue biopsies we analyzed AGT, renin, renin-receptor, ACE and AT1-receptor gene expression. Obese women (n=19) had higher circulating AGT, renin, aldosterone, and ACE than lean women (n=19), and lower AGT gene expression in adipose tissue. Seventeen women successfully participated in a weight reduction protocol over 13 weeks to reduce daily caloric intake by 600 kcal. Body weight was reduced by -5% as were: AGT levels by -27%, renin by -43%, aldosterone by -31%, ACE activity by -12%, and AGT expression by -20% in adipose tissue (all p<0.05). The plasma AGT decrease was highly correlated with the waist circumference decline (r=0.74; p<0.001). Weight and RAAS reduction were accompanied by a -7 mm Hg reduced systolic ambulatory blood pressure. These data suggest that a 5% reduction in body weight can lead to a meaningfully reduced RAAS in plasma and adipose tissue which may contribute to the reduced blood pressure.