Artikel
Molecular basis of a relation of tinnitus and stress
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Autoren
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Marlies Knipper
- HNO Klinik – Universität Tübingen, Tübingen
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Lukas Rüttiger
- HNO Klinik – Universität Tübingen, Tübingen
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Mirko Jaumann
- HNO Klinik – Universität Tübingen, Tübingen
| Veröffentlicht: | 15. April 2013 |
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Gliederung
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Introduction: Tinnitus is a non-curable stress-related brain disorder, that is mostly noise-induced and whose origin is unknown. We have addressed the molecular and physiological basis of this disease.
Methods: We used a combined approach that included behaviorally tested tinnitus (Rüttiger et al., Knipper, Hear Res 2003), hearing measurements (including DPOAEs, ABRs and ABR wave analysis) and markers that trace network activity (Arc/Arg3.1). We also included stress priming in animal models.
Results and Conclusion: Data analysed the first time equally hearing impaired animals that were behaviourally distinguished in hearing impaired animals with and without tinnitus. We compared animals between the periphery of the cochlea up to the auditory cortex, including the limbic system. We unraveled a tinnitus specific trait that may explain the relation of tinnitus and stress.
The findings are discussed in the context of the role of stress for tinnitus and other mood-related disorders
Supported by: This work was supported by the Marie Curie Research Training Network CavNET MRTN-CT-2006-035367, the Deutsche Forschungsgemeinschaft DFG-Kni-316-4-1 and Hahn Stiftung (Index AG).
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