Artikel
Thyroid carcinoma in nodular goiter
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Autoren
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Magdalena Chirila
- UMF Cluj-Napoca, Cluj-Napoca, Romania
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Mihaela Muresan
- Emergency County Hospital Cluj-Napoca, Romania, Romania
| Veröffentlicht: | 15. April 2013 |
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Gliederung
Text
Objective: To study the incidence and pathology of thyroid malignancy in patients operated for presumably benign nodular thyroid disease: multinodular goiter (MNG) and solitary thyroid nodule (STN).
Methods: A total of 45 patients who underwent surgery for presumably benign nodular thyroid disease between January 2011 and August 2012 were studied, prospectively. These patients underwent total thyroidectomy after intraoperative frozen sections.
Results: 11 of the 45 patients (24.4%) had malignancy on final pathological examination. The mean age of patients with benign disease was 46.4 years and that with malignancies was 50.6 years. Mean size of nodules was 4.28 ±1.48 cm in the benign group and 4.21 ±1.48 cm in the malignant group. All those with MNG, 5/5 (100%) were papillary carcinoma and those with STN, 5/6 (83.3%) were papillary carcinoma. Among the papillary carcinomas, follicular variant was 9 and the micropapillary variant was 2.
Conclusions: The incidence of malignancy in nodular goiter is higher than what is usually reported. There was no significant difference in incidence of malignancy between MNG and STN (p=0.262). Papillary carcinoma was significantly higher in nodular goiter. Follicular variant of papillary carcinoma was more common than the micropapillary variant.
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