gms | German Medical Science

64. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e. V. (GMDS)

Deutsche Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie

08. - 11.09.2019, Dortmund

Common risk factors for stroke not found to influence time to subsequent death after first ever stroke

Meeting Abstract

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  • Ann-Kathrin Ozga - Institut für Medizinische Biometrie und Epidemiologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany
  • Geraldine Rauch - Charité Universitätsmedizin Berlin, Berlin, Germany

Deutsche Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie. 64. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS). Dortmund, 08.-11.09.2019. Düsseldorf: German Medical Science GMS Publishing House; 2019. DocAbstr. 119

doi: 10.3205/19gmds094, urn:nbn:de:0183-19gmds0942

Veröffentlicht: 6. September 2019

© 2019 Ozga et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.


Gliederung

Text

Introduction: Risk factors for stroke include hypertension, diabetes mellitus, smoking, and high cholesterol [1] [2]. However, the role of those factors is usually only evaluated until the first cardiovascular event. The disease process after the first potential non-fatal event is thereby ignored. In this work, we want to examine whether the common risk factors for first ever stroke are also influencing time to death or subsequent stroke in the first year after stroke. Thereby a composite endpoint consisting of stroke and death is considered, where the event ‘death’ is clearly clinically more severe.

Methods: The case-control study on ‘Inflammatory, Genetic and Socio-economic Determinants of Ischemic Stroke and their Interdependence’ included 470 patients with first ever stroke as cases from the population based stroke registry ‘Ludwigshafen stroke study’ [3]. We used this population to examine the stability of known risk factors on time to death or subsequent stroke after a first stroke. To account for the higher impact of death compared to non-fatal stroke, we applied the recently introduced weighted all-cause hazard ratio [4], [5] and extended this approach to adjust for covariates. The potential risk factors hypertension, diabetes mellitus, smoking, hypercholesterolemia adjusting for gender and age were examined.

Results: For the 470 patients 57 time-to-first events were included with 23 death and 34 subsequent strokes and median time-to-event of 125 and 92, respectively. For the risk factors included no statistically significant effect on the rate for death or subsequent stroke after first ever stroke could be shown.

Discussion: Common risk factors for first ever stroke might not be a good predictor for time to death or subsequent stroke after first ever stroke. As a methodologic result, the recently proposed weighted all-cause hazard ratio can be extended to adjust for covariates.

The authors declare that they have no competing interests.

The authors declare that an ethics committee vote is not required.


References

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