gms | German Medical Science

21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin e. V.

Deutsches Netzwerk Evidenzbasierte Medizin e. V.

13. - 15.02.2020, Basel, Schweiz

A structured concept to increase registration of clinical studies at the University Hospital Basel (USB) – An overview and comparison with other Swiss University Hospitals

Meeting Abstract

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  • Constantin Sluka - Universitätsspital Basel, Department Klinische Forschung/CTU, Basel, Schweiz
  • Bettina Bannert - Universitätsspital Basel, Department Klinische Forschung/CTU, Basel, Schweiz
  • Christiane Pauli-Magnus - Universitätsspital Basel, Department Klinische Forschung/CTU, Basel, Schweiz

Nützliche patientenrelevante Forschung. 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin. Basel, Schweiz, 13.-15.02.2020. Düsseldorf: German Medical Science GMS Publishing House; 2020. Doc20ebmPP3-04

doi: 10.3205/20ebm070, urn:nbn:de:0183-20ebm0705

Veröffentlicht: 12. Februar 2020

© 2020 Sluka et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe



Background/research question: Prospective registration of trials is considered a scientific, ethical and moral responsibility by the WHO. Since 2014, registering clinical trials in a primary registry endorsed by the WHO or in is a legal requirement in Switzerland. To increase registration rates of interventional and particularly observational studies at the Universitätsspital Basel (USB) the Department of Clinical Research developed a systematic concept. Since 2018 we offer registration as service for every researcher at the USB. Here we compare the registration rates across Swiss University Hospitals, describe automated results reporting and investigate the effect of the new registration policy of the USB.

Methods: We export data of all clinical studies with a Swiss University Hospital as sponsor from, extract study information and metadata and examine registration patterns stratified by study characteristics. We automatically search publications using the NCT-ID for studies completed before 2018 (Powell-Smith and Goldacre 2016).

Results: As of September 2019, the 5 Swiss University Hospitals registered 1272 interventional and 770 observational studies. Inselspital Bern, USB and Universitätsspital Zürich registered 413, 540 and 751 studies, of which 47% , 34% and 37% were timely registered. The Centre hospitalier universitaire vauDOIs (CHUV) Lausanne and the Hôpitaux universitaires de Genève (HUG) registered studies less frequently and less timely. Overall, interventional studies are registered timelier than observational (42% vs 26%). In 2018, 79 studies were registered at the USB, 97% more than the annual average of the previous five years. Much of this increase is due to observational studies (plus 221%).

For 42% of interventional trials completed at least 2 years ago we found a publication automatically.

Conclusion: There are substantial differences of clinical study registration across Swiss University Hospitals, with lowest rates in the largest hospitals. The new registration policy of the USB leads to a duplication of the annually registered clinical studies.


Powell-Smith A, Goldacre B. The TrialsTracker: Automated ongoing monitoring of failure to share clinical trial results by all major companies and research institutions. F1000Res. 2016 Nov 3;5:2629. DOI: 10.12688/f1000research.10010.1 Externer Link