gms | German Medical Science

Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2016)

25.10. - 28.10.2016, Berlin

Do gastric bypass operations alter bone quality? Biomechanical investigations in a rat model

Meeting Abstract

  • presenting/speaker Sönke Frey - Klinik und Poliklinik für Orthopädie und Unfallchirurgie, Bonn, Germany
  • Kaya Dresing - Universitätsklinikum Würzburg, Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Würzburg, Germany
  • Stefanie Hölscher-Doht - Universitätsklinikum Würzburg, Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Würzburg, Germany
  • Kathrin Abegg - Institute of Veterinary Physiology, Vetsuisse Faculty University of Zurich, Zurich, Switzerland
  • Thomas A. Lutz - Institute of Veterinary Physiology, Vetsuisse Faculty University of Zurich, Zurich Center for Integrative Human Physiology, Zurich, Switzerland
  • Rahel Bornemann - Universitätsklinikum Bonn, Klinik und Poliklinik für Orthopädie und Unfallchirurgie, Bonn, Germany
  • Rainer Meffert - Universitätsklinikum Würzburg, Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Würzburg, Germany
  • Marco Büter - Zurich Center for Integrative Human Physiology, Dep. Surg., Div. of Visceral &Transplant. Surg., University of Zurich, Zurich, Switzerland

Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2016). Berlin, 25.-28.10.2016. Düsseldorf: German Medical Science GMS Publishing House; 2016. DocPO30-1240

doi: 10.3205/16dkou792, urn:nbn:de:0183-16dkou7928

Veröffentlicht: 10. Oktober 2016

© 2016 Frey et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.


Gliederung

Text

Objectives: Adipositas is becoming an emerging health and economic problem. Dieting and medication therapy are unsatisfying with high recidivism rates. The only treatment with positive long-term results is bariatric operative treatment. Among bariatric methods the Roux-en-Y-gastric bypass (RYGB) is the gold standard with a positive benefit-risk profile. There is some data that RYGB-operations may have an negative impact on bone quality. Currently, there is no relevant data about a reduced bone mineral density (BMD) and a higher fracture risk after bariatric bypass operations. Therefore we asked if there is a long-term influence after gastric bypass operations on bone quality in a rat model.

Methods: 18 male Wistar rats were randomised and divided into two equal groups. 9 rats underwent a RYGB-operation and the other 9 rats underwent a sham-operation. 200 days post surgery animals were sacrificed and the tibiae and femora were explanted for further biomechanical and radiological investigations.

Results and Conclusion: The quality of bone of RYGB-operated rats was significant inferior in strength and stiffness compared to the sham-group. Besides, microcomputertomography showed a significant lower BMD in RYGB-operated rats.

The often performed gastric bypass surgery (RYGB) has a negative impact on the bone quality.