gms | German Medical Science

68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
7. Joint Meeting mit der Britischen Gesellschaft für Neurochirurgie (SBNS)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

14. - 17. Mai 2017, Magdeburg

Artikel

Artikel empfehlen

Time-course of plasma chemokine and cytokine increases in a rat model of brain death

Meeting Abstract

Suche in Medline nach

  • Majid Esmaeilzadeh - Hannover, Deutschland
  • Mahmoud Sadeghi - Heidelberg, Deutschland
  • Roland Galmbacher - Hannover, Deutschland
  • Volker Daniel - Hannover, Deutschland
  • Arianeb Mehrabi - Heidelberg, Deutschland
  • Joachim K. Krauss - Medizinische Hochschule Hannover, Neurochirurgische Klinik, Klinik für Neurochirurgie, Hannover, Deutschland

Deutsche Gesellschaft für Neurochirurgie. Society of British Neurological Surgeons. 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS). Magdeburg, 14.-17.05.2017. Düsseldorf: German Medical Science GMS Publishing House; 2017. DocP 034

doi: 10.3205/17dgnc597, urn:nbn:de:0183-17dgnc5971

Veröffentlicht: 9. Juni 2017

© 2017 Esmaeilzadeh et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.

Gliederung

Text

Objective: Brain death (BD) is a donor-associated risk factor that negatively affects transplantation outcome. The inflammation associated with BD appears to have a negative effect on organ quality. It was shown that complement activation, apoptosis and pro-inflammatory cytokines and chemokines significantly increase after brain death. We determined plasma chemokine and cytokine responses over a period of eight hours after BD.

Methods: Thirteen healthy adult male Sprague Dawley rats were intubated and mechanically ventilated. After induction of BD, rats were kept hemodynamically stable over a period of eight hours. A panel of immune responses including cytokines and chemokines were measured at 1, 4 and 8 hours after BD by multiplex analyses.

Results: In the early phase after BD induction, an increase in heart rate and a decrease in mean arterial pressure (mMAP) were recorded. Only limited fluctuations in Pa O2, O2 saturation and HCO3 were noted. Almost all monocyte-/macrophage- and lymphocyte-derived cytokines and immune cell products increased steadily during a period of eight hours.

Conclusion: Increase of chemokines, cytokines and particularly pro-inflammatory responses after BD is significantly time-dependent. Studies which measure donors` and recipients` cytokines and chemokines could provide useful information to improve outcome for organ recipients.