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67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

12. - 15. Juni 2016, Frankfurt am Main

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Resting-state-fMRI vs. task-based fMRI. Sensitivity and specificity in comparison to direct cortical stimulation in eloquent areas

Meeting Abstract

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  • Christian Ott - Klinik und Poliklinik für Neurochirurgie, Klinikum der Universität Regensburg, Germany
  • Katharina Rosengarth - Klinik und Poliklinik für Neurochirurgie, Klinikum der Universität Regensburg, Germany
  • Markus Goldhacker - Lehrstuhl für experimentelle Psychologie, Universität Regensburg, Germany
  • Christian Doenitz - Klinik und Poliklinik für Neurochirurgie, Klinikum der Universität Regensburg, Germany
  • Alexander Brawanski - Klinik und Poliklinik für Neurochirurgie, Klinikum der Universität Regensburg, Germany

Deutsche Gesellschaft für Neurochirurgie. 67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS). Frankfurt am Main, 12.-15.06.2016. Düsseldorf: German Medical Science GMS Publishing House; 2016. DocMI.07.09

doi: 10.3205/16dgnc282, urn:nbn:de:0183-16dgnc2823

Veröffentlicht: 8. Juni 2016

© 2016 Ott et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.

Gliederung

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Objective: The aim of this study was the comparison of the sensitivity and specificity of preoperative resting-state and tasked-based fMRI according to the precise identification of critical language areas by direct cortical stimulation during awake craniotomy.

Method: 2 patients suffering from lesions close to critical language areas have been examined preoperatively to awake craniotomy by means of a task-based fMRI (verbgeneration) and a resting-state fMRI. The language network was identified in both patients by the task-based fMRI applying the general linear model approach and by the resting-state fMRI using independent component analysis independently. Intraoperatively, locations of positive and negative direct cortical stimulation (according to language) were mapped by using the Brainlab system in an awake surgery setting. Postoperatively the sensitivity and the specificity of task-based fMRI and resting-state fMRI according to direct stimulation were analyzed.

Results: According to our preliminary results task-based fMRI as well as resting-state fMRI reached a sensitivity of 100% while the specificity was 50% for the task-based fMRI and 60% for the resting-state fMRI.

Conclusions: The high sensitivity of this preliminary data indicates the resting-state and task-based fMRI might both be valid methods to predict eloquent areas. Although the specificity is low in both methods the resting-state fMRI might be a more precise approach to determine real false negatives. Hence, further studies are needed to evaluate the neurosurgical use of resting state fMRI.