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67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

12. - 15. Juni 2016, Frankfurt am Main

Population-wide MRI-screening for early detection of glioblastoma? Considerations from a naturally occurring “Screening-Like” setting

Meeting Abstract

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  • Roland Roelz - Klinik für Neurochirurgie, Universitätsklinikum Freiburg, Freiburg, Germany
  • Istvan Csok - Klinik für Neurochirurgie, Universitätsklinikum Freiburg, Freiburg, Germany
  • Astrid Weyerbrock - Klinik für Neurochirurgie, Universitätsklinikum Freiburg, Freiburg, Germany
  • Peter Reinacher - Stereotaktische und Funktionelle Neurochirurgie, Universitätsklinikum Freiburg, Freiburg, Germany

Deutsche Gesellschaft für Neurochirurgie. 67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS). Frankfurt am Main, 12.-15.06.2016. Düsseldorf: German Medical Science GMS Publishing House; 2016. DocDI.08.08

doi: 10.3205/16dgnc143, urn:nbn:de:0183-16dgnc1432

Veröffentlicht: 8. Juni 2016

© 2016 Roelz et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.


Gliederung

Text

Objective: Despite all medical efforts, the prognosis of patients with a new diagnosis of glioblastoma multiforme (GBM) remains very poor. Complete surgical removal of the lesion as visualized by MRI correlates with improved overall survival. Population-wide MRI-Screening could potentially lead to early diagnoses of GBM in statu nascendi and – combined with radical supratotal surgical therapy – improve patient survival.

Method: We reviewed the imaging records of all patients with a first histological diagnosis of GBM between 2004 and 2014 in our center for the presence of unremarkable cranial imaging prior to the diagnosis of GBM.

Results: 19 of 950 patients with a histological diagnosis of GBM had a previous imaging (13 MRI, 6 CT) without visible abnormities indicating a brain tumor at a median time of 1.7 years (range: 0.3 – 9.5 years) prior to the diagnosis of GBM. Imaging was performed due to cerebrovascular events in 4, headache in 3, neurological symptoms in 5 and unknown reasons in 7 patients. In 4 patients GBM emergence from an invisible lesion to a mean 4.5 cm tumor diameter was documented within less than 6 months.

Conclusions: Unremarkable MRI and CT may be obtained 4 - 6 months prior to the diagnosis of large GBM. The explosive growth kinetics of GBM seem to preclude the feasibility of a population-wide MRI-screening.