gms | German Medical Science

67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

12. - 15. Juni 2016, Frankfurt am Main

Artikel

Artikel empfehlen

Skewness of the distribution of ADC values of the enhancing tumor portion is associated with survival after the second resection in glioblastoma recurrence

Meeting Abstract

Suche in Medline nach

  • Amir Zolal - Klinik und Poliklinik für Neurochirurgie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Germany
  • Dino Podlesek - Klinik und Poliklinik für Neurochirurgie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Germany
  • Gabriele Schackert - Klinik und Poliklinik für Neurochirurgie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Germany
  • Jennifer Linn - Institut und Poliklinik für Neuroradiologie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Germany
  • Dietmar Krex - Klinik und Poliklinik für Neurochirurgie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Germany

Deutsche Gesellschaft für Neurochirurgie. 67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS). Frankfurt am Main, 12.-15.06.2016. Düsseldorf: German Medical Science GMS Publishing House; 2016. DocDI.08.04

doi: 10.3205/16dgnc139, urn:nbn:de:0183-16dgnc1393

Veröffentlicht: 8. Juni 2016

© 2016 Zolal et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.

Gliederung

Text

Objective: In contrast to mean ADC (apparent diffusion coefficient) values, ADC histogram parameters were shown to be associated with survival in patients with glioblastoma, as well as with their genetic composition. In theory, the ADC histogram parameters should reflect the internal tissue composition of the sampled volume by providing insights in the distribution of ADC values. We aimed to determine the value of ADC histogram analysis in recurrent glioblastoma multiforme, where possible post-treatment changes are often present along with viable tumor.

Method: Using our internal tumor database, we have identified thirty-one patients who have been operated on in our department on first glioblastoma recurrence between 2008 and 2012. Various ADC histogram parameters were collected from the enhancing tumor portion, including skewness, kurtosis, and fifth percentile of the histogram along with clinical parameters and compared statistically with survival after the second surgery. Further treatment after the second operation has been controlled for.

Results: The distribution skewness of the ADC values in the enhancing tissue was significantly associated with the postoperative survival following second surgery using log-rank test (p<0.01). No other significant histogram parameter could be identified, however, recurrent tumor size was also significantly associated with survival (p=0.04).

Conclusions: ADC histogram skewness is associated with survival in patients with recurrent glioblastoma multiforme undergoing resection of the recurrence.