Artikel
Skewness of the distribution of ADC values of the enhancing tumor portion is associated with survival after the second resection in glioblastoma recurrence
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Veröffentlicht: | 8. Juni 2016 |
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Gliederung
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Objective: In contrast to mean ADC (apparent diffusion coefficient) values, ADC histogram parameters were shown to be associated with survival in patients with glioblastoma, as well as with their genetic composition. In theory, the ADC histogram parameters should reflect the internal tissue composition of the sampled volume by providing insights in the distribution of ADC values. We aimed to determine the value of ADC histogram analysis in recurrent glioblastoma multiforme, where possible post-treatment changes are often present along with viable tumor.
Method: Using our internal tumor database, we have identified thirty-one patients who have been operated on in our department on first glioblastoma recurrence between 2008 and 2012. Various ADC histogram parameters were collected from the enhancing tumor portion, including skewness, kurtosis, and fifth percentile of the histogram along with clinical parameters and compared statistically with survival after the second surgery. Further treatment after the second operation has been controlled for.
Results: The distribution skewness of the ADC values in the enhancing tissue was significantly associated with the postoperative survival following second surgery using log-rank test (p<0.01). No other significant histogram parameter could be identified, however, recurrent tumor size was also significantly associated with survival (p=0.04).
Conclusions: ADC histogram skewness is associated with survival in patients with recurrent glioblastoma multiforme undergoing resection of the recurrence.