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67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

12. - 15. Juni 2016, Frankfurt am Main

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Influence of demineralized bone matrix on clinical and radiological outcome in anterior cervical discectomy and fusion

Meeting Abstract

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  • Ehab Shiban - Klinik für Neurochirurgie, Technische Universität München, München, Germany
  • Johannes Kogler - Klinik für Neurochirurgie, Technische Universität München, München, Germany
  • Moritz Nies - Klinik für Neurochirurgie, Technische Universität München, München, Germany
  • Lorenz Kogler - Klinik für Neurochirurgie, Technische Universität München, München, Germany
  • Bernhard Meyer - Klinik für Neurochirurgie, Technische Universität München, München, Germany
  • Jens Lehmberg - Klinik für Neurochirurgie, Technische Universität München, München, Germany

Deutsche Gesellschaft für Neurochirurgie. 67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS). Frankfurt am Main, 12.-15.06.2016. Düsseldorf: German Medical Science GMS Publishing House; 2016. DocMO.14.05

doi: 10.3205/16dgnc078, urn:nbn:de:0183-16dgnc0785

Veröffentlicht: 8. Juni 2016

© 2016 Shiban et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.

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Objective: Demineralized bone matrix (DBM) is being used to fill cages in cervical interbody fusion in order to reduce the non-fusion rates. However, comparative data is still missing. Our aim is to evaluate the influence of DBM on radiological and clinical outcome after anterior cervical discectomy and fusion (ACDF) with stand-alone PEEK cages.

Method: A retrospective age-, gender- and number of levels-matched pair analysis was performed on 200 patients, who underwent anterior cervical discectomy and fusion (ACDF) with stand-alone PEEK cages with a minimum follow-up of 12 months. In the study group, DBM was used as an osteogenic filling substance. Radiographic follow-up included static and flexion/extensionX-rays. Changes in the operated segments were measured and compared to radiographs directly after surgery. Clinical outcome was evaluated the EuroQOL questionnaire (EQ-5D).

Results: 45% of patients were female. Mean age was 55 years. Mean follow-up was 30 months. Fusion rate was higher in the control group (84% vs. 72%; p=0.06). Subsidence rate was higher in the study group (40% vs 19%, p=0.001). VAS Overall Health increased from 42 ± 25 to 72 ± 22 in the study group and from 41 ± 24 to 71 ± 22 in the control group (p=0.75).

Conclusions: Application of DBM for ACDF with stand-alone PEEK Cages may have a negative influence on fusion. There was a trend towards impaired fusion with DBM. This, however, did not reach statistical significance. Also, DBM application correlated with significantly higher subsidence rates. There was no influence on clinical outcome.