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67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

12. - 15. Juni 2016, Frankfurt am Main

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Brain arteriovenous malformations: implications of CEACAM1-positive inflammatory cells and sex on hemorrhage

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  • Belal Neyazi - Klinik für Neurochirurgie, KRH Klinikum Nordstadt, Hannover, Germany
  • Angelika Herz - Klinik für Neurochirurgie, KRH Klinikum Nordstadt, Hannover, Germany
  • Klaus-Peter Stein - Klinik für Neurochirurgie, KRH Klinikum Nordstadt, Hannover, Germany
  • Islam Gawish - Klinik für Neurochirurgie, KRH Klinikum Nordstadt, Hannover, Germany
  • Claudia A. Dumitru - Klinik für Neurochirurgie, KRH Klinikum Nordstadt, Hannover, Germany
  • I. Erol Sandalcioglu - Klinik für Neurochirurgie, KRH Klinikum Nordstadt, Hannover, Germany

Deutsche Gesellschaft für Neurochirurgie. 67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS). Frankfurt am Main, 12.-15.06.2016. Düsseldorf: German Medical Science GMS Publishing House; 2016. DocMO.12.07

doi: 10.3205/16dgnc063, urn:nbn:de:0183-16dgnc0633

Veröffentlicht: 8. Juni 2016

© 2016 Neyazi et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.

Gliederung

Text

Objective: Brain arteriovenous malformations (bAVM) are severe conditions which, upon rupture, cause debilitating neurological deficits and even death. The exact cellular/ molecular mechanisms associated with bAVM rupture are currently unclear. The objective of this study was to explore the potential role of CEACAM1 (CEA-related cell adhesion molecule-1) in bAVM pathophysiology.

Method: Expression and localization of CEACAM1 were assessed immunohistochemically in tissue microarrays from bAVM patients (n=60). The association of CEACAM1 with clinical parameters was analysed with Spearman's rank correlation coefficient and Chi-square test. The predictive value of CEACAM1 was tested using logistic regression analysis.

Results: CEACAM1 was highly expressed in tissue-infiltrating neutrophil granulocytes. High levels of CEACAM1-positive cells were associated with bAVM rupture (hemorrhage), but not with AVM size, preoperative embolization or seizure. Notably, this association was significant (p=0.029, Chi-square) in male but not in female patients. Furthermore, high CEACAM1-positive immune infiltration was a predictor of hemorrhage (OR=6.50, 95% CI 1.09-38.63, p=0.040) only in male bAVM patients.

Conclusions: Our findings substantiate the importance of inflammation in bAVM progression and provide the first evidence that sexual dimorphism exists in bAVM. These findings contribute to a better understanding of the bAVM microenvironment, which may ultimately foster the development of improved therapeutic strategies against this disease.