gms | German Medical Science

67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

12. - 15. Juni 2016, Frankfurt am Main

Gender-specific growth dynamics of neurofibromatosis-type-2-related tumors of the central nervous system

Meeting Abstract

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  • Anna Lawson McLean - HELIOS Klinikum Erfurt, Germany; Friedrich-Schiller-Universität Jena, Germany
  • Steffen Rosahl - HELIOS Klinikum Erfurt, Germany

Deutsche Gesellschaft für Neurochirurgie. 67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS). Frankfurt am Main, 12.-15.06.2016. Düsseldorf: German Medical Science GMS Publishing House; 2016. DocMO.10.06

doi: 10.3205/16dgnc045, urn:nbn:de:0183-16dgnc0452

Veröffentlicht: 8. Juni 2016

© 2016 Lawson McLean et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.


Gliederung

Text

Objective: Neurofibromatosis type 2 (NF2) is an autosomal-dominant genetic disorder characterized by multiple tumors of the central nervous system. Little is known is known about the growth dynamics of neoplasms in patients with NF2. Only few volumetric studies on this topic have been published, in which gender-specific growth rates and spinal tumors have mostly been neglected. The aim of this study was to evaluate the gender-specific tumor burden and growth dynamics of both intracranial and intramedullary spinal tumors in patients with NF2.

Method: 40 NF2 patients (20 female, 20 male) were included in this study. The two groups were matched according to age at first available imaging investigation (p=0.817). All available magnetic resonance imaging (MRI) data of the included patients were collected. The amount of tumors per patient was quantified and tumor volumes were determined by volumetric extrapolation after segmentation in datasets (iPlanNet software, Brainlab, Munich). For statistical analysis, “survrec” and “TestSurvRec” packages of R were utilized and progression-free intervals were calculated by using the Peña-Strawderman-Hollander model for recurrent survival analysis. Significance was calculated using the Wilcoxon signed-rank test in R package “stats” and determined as p≤0.5.

Results: The median follow-up time per patient was 91 months (16 - 199 months). Intracranial tumors: On average, male patients harbored 7 tumors, whereas females had 13 tumors per patient (p=0.042). Overall, the median time to tumor growth was 18 months for tumors in male patients and 20 months for those in female patients (p=0.858). Tumors of the cerebellopontine angle that had undergone previous surgery had longer growth-free intervals in the male group than in the female group (24 versus 16 months, p=0.012). The median one-year growth rate ± standard deviation was 12.5 ± 44.9% for tumors in males and 17.5 ± 44.6% for those in females. Intramedullary spinal tumors: There was no statistically significant difference of the tumor load in male and female patients (p=0.721): in both groups there were 2 neoplasms per patient. The median time to tumor progression was 44 months in males and 21 months in females (p= 0.204). The median growth rate after two years was 13.5 ± 40.4% for tumors in males and 24.4 ± 56.8% for tumors in females (p=0.813).

Conclusions: These radiographic follow-up data indicate that the female population appears to be more severely affected by NF2 than males.