gms | German Medical Science

67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

12. - 15. Juni 2016, Frankfurt am Main

Long-term outcome in orbital meningiomas: progression-free survival after targeted resection combined with early or postponed postoperative radiotherapy

Meeting Abstract

  • Nicole A. Terpolilli - Klinik und Poliklinik für Neurochirurgie, Klinikum der Ludwig-Maximilians-Universität München, Standort Großhadern, München, Germany
  • Moritz Ueberschaer - Klinik und Poliklinik für Neurochirurgie, Klinikum der Ludwig-Maximilians-Universität München, Standort Großhadern, München, Germany
  • K.-Maximilian Niyazi - Klinik und Poliklinik für Strahlentherapie und Radioonkologie, Klinikum der Ludwig-Maximilians-Universität München, Standort Großhadern, München, Germany
  • Niklas Thon - Klinik und Poliklinik für Neurochirurgie, Klinikum der Ludwig-Maximilians-Universität München, Standort Großhadern, München, Germany
  • Jörg-Christian Tonn - Klinik und Poliklinik für Neurochirurgie, Klinikum der Ludwig-Maximilians-Universität München, Standort Großhadern, München, Germany
  • Christian Schichor - Klinik und Poliklinik für Neurochirurgie, Klinikum der Ludwig-Maximilians-Universität München, Standort Großhadern, München, Germany

Deutsche Gesellschaft für Neurochirurgie. 67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS). Frankfurt am Main, 12.-15.06.2016. Düsseldorf: German Medical Science GMS Publishing House; 2016. DocMO.04.03

doi: 10.3205/16dgnc017, urn:nbn:de:0183-16dgnc0177

Veröffentlicht: 8. Juni 2016

© 2016 Terpolilli et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.


Gliederung

Text

Objective: In meningeomas involving orbit and optic canal, surgical resection is standard of care. However, radical resection is often limited in order to avoid functional damage so multidisciplinary treatment concepts are implemented. Data on timing and value of postoperative radiotherapy are sparse. Here we analyzed functional outcome and tumor control in patients harboring orbital meningiomas, treated by either surgery alone or in combination with postoperative radiotherapy.

Method: Patients that underwent resection of orbit associated meningiomas from 01/00-12/13 and presented to our outpatient department at least twice for follow-up were included. Clinical and radiological findings from our in-house database were analyzed retrospectively. We evaluated patients that were followed up with MRI alone and those that received scheduled adjuvant therapy within the first 6 months after operation.

Results: 76 meningioma patients were included (WHO°I: 74; WHO° II: 2), median follow-up was 60 months. Most common symptoms upon presentation were visual disturbances (loss of visual acuity, visual field defects, exophthalmus), and headache. In order to avoid functional deficits, 75% of patients received targeted partial resection (Simpson II-III). In 14 cases, adjuvant therapy was scheduled postoperatively: 9 patients (11.8%) were treated with stereotactic radiosurgery, 5 (6.6%) received external beam radiation within 6 months after the operation; the other patients were followed up with regular MRI scans. In case of recurrence, progression free survival (PFS) was 28 months after operation (47.4%, n=36): 3/14 patients treated with adjuvant radiosurgery or fractionated stereotactic radiotherapy and 33/62 of those that were followed up with MRI developed recurrent tumor growth so far. 22/36 patients were operated in case of recurrence, of whom 16 subsequently received radiotherapeutic treatment. 5/22 that were followed up with MRI alone after surgery for recurrency developed further symptomatic tumor growth necessitating surgery; the majority (80%) then received external beam radiation postoperatively.

Conclusions: Targeted partial resection is a reasonable treatment concept in orbital meningiomas. Our data indicate that postoperative radiation therapy early after targeted partial resection might help to postpone tumor recurrency and need for additional surgery. However, further analysis and prospective studies are needed to corroborate these findings.