gms | German Medical Science

65. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

11. - 14. Mai 2014, Dresden

Artikel

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Resection of central nervous system lymphoma – a paradigm shift?

Meeting Abstract

Suche in Medline nach

  • Nina Brawanski - Abteilung für Neurochirurgie, Goethe-Universität Frankfurt am Main
  • Lutz Martin Weise - Abteilung für Neurochirurgie, Goethe-Universität Frankfurt am Main
  • Gerhard Marquardt - Abteilung für Neurochirurgie, Goethe-Universität Frankfurt am Main
  • Marlies Wagner - Abteilung für Neuroradiologie, Goethe-Universität Frankfurt am Main
  • Volker Seifert - Abteilung für Neurochirurgie, Goethe-Universität Frankfurt am Main
  • Christian Senft - Abteilung für Neurochirurgie, Goethe-Universität Frankfurt am Main

Deutsche Gesellschaft für Neurochirurgie. 65. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC). Dresden, 11.-14.05.2014. Düsseldorf: German Medical Science GMS Publishing House; 2014. DocP 084

doi: 10.3205/14dgnc480, urn:nbn:de:0183-14dgnc4805

Veröffentlicht: 13. Mai 2014

© 2014 Brawanski et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.

Gliederung

Text

Objective: Primary central nervous system lymphomas (PCNSL) are regarded as non-surgically treated tumors with a poor prognosis. Usually, only stereotactic biopsy is performed to establish the diagnosis, and most patients show disease progression within half a year. A recent study (Weller et al. 2012) questioned this view, since patients who had surgical resection of PCNSL manifestations prior to adjuvant therapy had a better outcome than patients who had biopsy only.

Method: We performed a retrospective analysis of our patient database to identify patients with PCNSL who had undergone “accidental” tumor removal in our department between 2002 and 2013. All patients had PCNSL specific therapy followed surgery.

Results: 4 patients with PCNSL were treated surgically. Two patients have remission at 3 and 13 months postoperatively, while two others had disease progression at 16 and 23 months, respectively.

Conclusions: Gross total removal of PCNSL may improve outcome. We present 3 patients who had progression-free intervals of more than 12 months after surgery. While the importance of chemotherapy is beyond doubt, more data on the effect of surgery on the prognosis of patients with PCNSL are needed. However the paradigm of medical treatment only is being challenged.