Artikel
Impact of intraoperative imaging modalities on overall survival of patients following GTR of brain metastases
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Veröffentlicht: | 13. Mai 2014 |
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Gliederung
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Objective: To analyze the impact of intraoperative resection control modalities on overall survival (OS) and tumor recurrence in 3-months postoperative magnetic resonance imaging (MRI) following gross-total resection (GTR) of brain metastases.
Method: Medical charts of 116 consecutive patients (68f, mean age 59.3±12.9 years) operated between 2009 and 2012 were included in case GTR was achieved as evaluated by the early postoperative high-field MRI. Intraoperative resection control modalities comprised intraoperative ultrasound (ioUS, n=64), intraoperative low-field MRI (ioMRI, n=13), neither modality (n=35), and a group with a combination of ioUS and ioMRI (n=4). The endpoint of our study was overall survival (OS) – analyzed in a Kaplan-Meier-Plot and a Cox-Proportional-Hazards-Model. The secondary endpoint was tumor recurrence after 3 months.
Results: In a multivariate Cox-Model comparing OS between the intraoperative resection control modalities (adjusted for gender, age, preOP Karnofsky) no statistically significant signal was found. Also, no significant difference between the groups was found regarding the rate of tumor recurrence at 3 months.
Conclusions: There is neither a significant difference in OS nor in tumor recurrence at 3 months between the analyzed intraoperative resection control modalities.