Artikel
Continued statin therapy reduces mortality after spontaneous intracerebral haemorrhage without effect on long-term functional outcome
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Autoren
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Jorge Humberto Tapia-Pérez
- Klinik für Neurochirurgie, Otto von Guericke Universität, Magdeburg, Deutschland
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Zilke Robert
- Klinik für Neurochirurgie, Otto von Guericke Universität, Magdeburg, Deutschland
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Firsching Raimund
- Klinik für Neurochirurgie, Otto von Guericke Universität, Magdeburg, Deutschland
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Schneider Thomas
- Klinik für Neurochirurgie, Otto von Guericke Universität, Magdeburg, Deutschland
| Veröffentlicht: | 21. Mai 2013 |
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Gliederung
Text
Objective: Spontaneous intracerebral haemorrhage (ICH) is often fatal. Some studies have suggested an improvement of short-term outcome in ICH-patients using statins. We analyzed, the long-term outcome after continued treatment with statins in ICH.
Method: We analyzed 387 patients with spontaneous ICH from a retrospective series treated between 2007 and 2011. Mortality after 1, 3, 6, and 12 months as well as GOS and Barthel index in long-term follow-up were outcome variables. Cox regression was achieved at different points of time.
Results: 57 patients continued a statin therapy in the acute phase after ICH. An increased number of patients with diabetes and hypertension as well as patients with arrhythmias under anticoagulation or anti-aggregant therapy were found in the statin group. The Cox-survival analysis showed a significantly positive effect of statin concerning 30-day mortality (HR=0.34, 95% CI 0.15–0.78, p=0.011) and 1-year mortality (HR= 0.65, 95% CI 0.41–1.02, p=0.065). No difference in GOS or Barthel index was found.
Conclusions: The continued use of statins after an ICH seems to reduce mortality, however no evidence of improvement on long-time functional outcome was observed. The actual evidence even in long-term follow-up justifies the conduction of randomized clinical trials for consideration of statins as an adjuvant therapy for patients with ICH.
